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NCT Number: NCT02393235

A Comparative Analysis of Arterial Blood Flow in Unexplained Infertility, Tubal Infertility and Fertile Groups

Factors affecting the success of the treatment of infertility can evaluate before and after embryo transfer in two stages. Most of the patients reach the embryo transfer stage. Unfortunately, the investigators are able to intervene very few of the factors that will affect the success of the post-transfer. All factors and treatments that affect the implantation is vital to identify. Basically, healthy vasculature is essential for a successful implantation. The investigators will try to understand relationship between vascular resistance and type of infertility. The investigators will examine whether the effect of the ovarian uterine and spiral artery resistance over infertility.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

22 year–37 year

Sex eligibility

Female

Study type

Observational

Primary location

Suleymaniye Birth And Women's Health Education And Research Hospital

Istanbul, 34020, Turkey (Türkiye)

About this study

In this study the investigators will examine whether the alterations of doppler indices in the uterine, ovarian and spiral arteries can help to explain tubal or unexplained infertility as a standard screening method. Patients in unexplained-tubal infertility groups were treated in our IVF clinic. Patients will be invited to the hospital according to the criteria of the study. Fertile patients will be selected according to the criteria for patients who have come for the annual smear control. The study hypothesis is that the resistance in ovarian, uterine and spiral artery doppler will be higher in cases with tubal and unexplained infertility as opposed to low resistance in fertile women.Ovarian, uterine and spiral artery pulsatility index (PI = (peak systolic velocity - end diastolic velocity) / time averaged velocity and resistance index ( RI= (peak systolic velocity - end diastolic velocity) / peak systolic velocity ) will measure with doppler ultrasonography in the mid-luteal phase ( 21th day). Measured values are to be compared.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • unsuccessful infertility treatment
  • normal prolactin levels
  • normal thyroid stimulation hormone levels
  • no ovarian or pelvic surgery history

Exclusion criteria

  • To have systemic diseases
  • receive medical treatments which may influence the clearance or excretion of gonadotropins and sex steroids

Treatment and study plan

Doppler ultrasonography

Other

Ovarian, uterine and spiral artery pulsatility index and resistance index will measure

Primary outcomes

  1. The primary outcome measure of this study is to evaluate the possible difference in ovarian artery impedance to blood flow ( RI and PI) among unexplained infertility, tubal infertility and fertile group.

    Time frame: 2-3 month

  2. The primary outcome measure of this study is to evaluate the possible difference in uterine artery impedance to blood flow (RI and PI) among unexplained infertility, tubal infertility and fertile group.

    Time frame: 2-3 month

  3. The primary outcome measure of this study is to evaluate the possible difference in spiral artery impedance to blood flow ( RI and PI) among unexplained infertility, tubal infertility and fertile group.

    Time frame: 2-3 month

Sponsors and collaborators

Lead sponsor

Suleymaniye Birth And Women's Health Education And Research Hospital

Other Gov

Collaborators

  • Bagcilar Training and Research Hospital

Registry information

Official study title

A Comparative Analysis of Ovarian, Uterine and Spiral Arterial Blood Flow in Unexplained Infertility, Tubal Infertility and Fertile Groups

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Mar 19, 2015
Registry last updated
Jul 7, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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