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NCT Number: NCT07241195

A Community-based Prospective Cohort Study on Metabolic Dysfunction-Associated Fatty Liver Disease in Older Adults: From Metabolic Trajectories to Extrahepatic Outcomes

To establish a cohort of elderly fatty liver disease based on the community medical examination population. Through the large-scale cohort study, the risk factors affecting fatty liver in the elderly will be explored in depth from the aspects of lifestyle, environment and genetics, the development pattern and mechanism of fatty liver in the elderly will be analysed, and the health risk assessment system and Chinese standard for fatty liver in the elderly covering cardiovascular risk, risk of hepatic fibrosis and risk of sarcopenia will be established, so as to provide the scientific basis for the precise intervention of fatty liver in the elderly in China.

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Key information

Conditions

NAFLD and NASH Digestive System Diseases Fatty Liver Liver Diseases NAFLD Cirrhosis NAFLD( Non-alcoholic Fatty Liver Disease ) Non-alcoholic Fatty Liver Disease

Age range

65 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

NO.518 Shangtang Road

Hangzhou, Zhejiang, 310015, China

Location status: Recruiting

Location contact

Wei Zhang, Dcotot's degree

CONTACT

[email protected]

86+13567135527

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ① Elderly people aged ≥65 years among permanent residents (living for more than 5 years) in the survey area;
  • Imaging diagnosis (ultrasound or FibroScan/FibroTouch) of fatty liver; -③ Voluntary participation in this study and signing an informed consent form.

Exclusion criteria

  • ①Major disability, mental illness, major wasting disease, severe cardiac, pulmonary and renal insufficiency;
  • Patients with combined primary liver cancer or other types of cancer; -③Patients who have received liver transplant or other organ transplants.

Treatment and study plan

Primary outcomes

  1. Incidence of liver fibrosis

    Time frame: 2 years

Secondary outcomes

  1. Incidence of cardiovascular disease

    Time frame: 2 years

  2. Incidence of sarcopenia

    Time frame: 2 years

Study contacts

Contact information is provided by the study sponsor or research team.

Wei Zhang, DR

CONTACT

[email protected]

+8613567135527

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Hangzhou Normal University

Other

Registry information

Official study title

Study on the Construction of Disease Cohort for Fatty Liver in the Elderly and Its Prevention and Treatment Strategies

Acronym: COMET cohort

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Nov 21, 2025
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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