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NCT Number: NCT05922540

a Cohort Study of Ischemic Cerebrovascular Disease

This study aims to establish a multicenter, large-scale, prospective cohort of patients with ischemic stroke. Various biological samples such as blood, feces, and urine are collected to identify biomarkers associated with ischemic stroke. By integrating demographic information, clinical indicators, imaging parameters, and biomarker parameters, the study aims to develop risk assessment, early warning, and prognosis prediction models. Additionally, the study aims to identify key genes and explore relevant signaling pathways related to ischemic stroke.

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Key information

Conditions

Ischaemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Xiangya Hospital, Central South University

Hunan, 410008, China

Location status: Recruiting

Location contact

jian xia, MD

CONTACT

[email protected]

13974880765

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of ischemic stroke.
  • Age ≥ 18 years.
  • Signed informed consent form.

Exclusion criteria

  • Patients with moderate to severe mental disorders or dementia who cannot cooperate to complete the informed consent and follow-up procedures.
  • Patients with neurological functional impairment caused by conditions such as migraine aura, epilepsy, or other non-ischemic strokes.
  • Agitated patients who cannot cooperate with imaging examinations.
  • Pregnant or lactating patients, as well as those planning to become pregnant within 90 days.
  • Patients with concurrent malignant tumors or severe systemic diseases with an expected survival period of less than 90 days.
  • Patients who have participated in other clinical studies within 30 days prior to enrollment or are currently participating in other interventional clinical studies.

Treatment and study plan

Intravenous thrombolysis

Other

Intravenous thrombolysis with alteplase within the time window of stroke onset in stroke patients

Primary outcomes

  1. Cerebrovascular events

    Time frame: 3 months of onset in patients

    Cerebrovascular events, including ischemic stroke, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage

  2. mRS scores

    Time frame: 3 months of onset in patients

    Assessing patients' neurological functional impairment status using the mRS score

Sponsors and collaborators

Lead sponsor

Xiangya Hospital of Central South University

Other

Registry information

Official study title

a Prospective, Multicenter Cohort Study of Ischemic Cerebrovascular Disease

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Jun 28, 2023
Registry last updated
Jun 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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