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NCT Number: NCT07674914

A Cognitive Mobile Intervention for Motivation in Psychotic Disorders

The goal of this study is to develop and test the impact of a smartphone-based working memory cognitive training digital therapeutic for individuals with schizophrenia or a related disorder.

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Key information

Conditions

Schizophrenia / Schizoaffective Disorder Mental Disorders Psychotic Disorders Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States

Location contact

Lauren Luther, Ph.D.

CONTACT

[email protected]

205-530-1117

Lauren Luther, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of schizophrenia, schizoaffective disorder, or a related psychotic disorder
  • own a smartphone
  • English speaking
  • experiencing challenges with cognitive functioning
  • no changes to antipsychotic medication in past month

Exclusion criteria

  • history of neurological disorder
  • traumatic brain injury with loss of consciousness > 10 minutes or behavioral sequelae.

Treatment and study plan

Cognitive training

Behavioral

This will be a digital cognitive training program.

Mobile cognitive training

Behavioral

This will be a remotely delivered mobile cognitive intervention via a smartphone application.

Primary outcomes

  1. Change in number correct in letter number span working memory test

    Time frame: Day 1 and Day 16

    Full scale of 24 items

Study contacts

Contact information is provided by the study sponsor or research team.

Lauren Luther, PhD

CONTACT

[email protected]

205-530-1117

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

  • UAB CEDHARS

Registry information

Official study title

A User-Informed Digital Therapeutic for Specific Cognitive Disabilities to Improve Mental Health in Schizophrenia and Related Mental Illnesses

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Jun 30, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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