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Completed

NCT Number: NCT07740161

A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility

This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the test product daily in the morning with their first meal.

Participants will complete questionnaires at Baseline, Month 1, Month 2, and Month 3. Semen analysis will be conducted at home at Baseline and Month 3, and blood testing will be performed at a local Labcorp location at Baseline and Month 3. The primary focus is on sperm quality parameters and testosterone levels, while secondary endpoints capture participants' perceptions of changes in reproductive and sexual health, including energy and libido.

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Key information

Conditions

Male Infertility Genital Diseases Genital Diseases, Male Infertility Infertility, Male Low Energy Low Libido Low Sperm Quality Low Testosterone Male Urogenital Diseases Urogenital Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Citruslabs

Las Vegas, Nevada, 89118, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be male
  • Be aged 30+
  • Anyone currently experiencing issues regarding low energy and low libido
  • Anyone who is generally healthy - does not live with any uncontrolled chronic disease
  • Willing to stop taking any other products or prescription medication, herbal remedies, or supplements for the duration of the study that target fertility, reproductive health, and sexual health
  • Not planning on introducing any products or any new prescription medication, herbal remedies, or supplements that target male fertility, reproductive health, or sexual health for the study duration
  • Resides in the United States
  • Not currently partaking in another research study and will not be partaking in any other research study for the next 3 months and at any point during this study's duration
  • Willing to provide a semen sample via masturbation
  • Willing to abstain from ejaculation for a minimum of 48 hours and a maximum of 5 days before providing the semen sample
  • Willing to abstain from marijuana products during the entire study duration

Exclusion criteria

  • Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
  • Anyone who has ever taken supplemental testosterone
  • Anyone planning to undergo any surgeries or invasive treatments for the study duration
  • Anyone who has had a major illness in the last 3 months
  • Anyone currently undergoing any type of fertility treatment
  • Anyone with any allergies or sensitivities to any of the study product ingredients
  • Anyone unwilling to follow the study protocol
  • Anyone taking anticoagulant or 'blood thinner' medication
  • Anyone undergoing chemotherapy
  • Anyone taking insulin or diabetes medication
  • Anyone who drinks heavily (i.e. 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men)
  • Anyone with a history of substance abuse
  • Anyone who is currently a smoker or has been a smoker in the past 3 months

Treatment and study plan

WeNatal For Him Supplement

Dietary Supplement

All participants take 3 capsules of the WeNatal For Him supplement daily in the morning with their first meal for 3 months.

Primary outcomes

  1. Change in Testosterone (Free and Total)

    Time frame: Baseline and Month 3

    Assessed via blood test at a local Labcorp location measuring free and total testosterone levels

  2. Change in Sperm Volume

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  3. Change in Sperm Concentration

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  4. Change in Sperm Count

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  5. Change in Sperm Motility

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  6. Change in Total Motile Count

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  7. Change in Sperm Morphology

    Time frame: Baseline and Month 3

    Assessed via at-home semen analysis using the Fellow Semen Analysis kit

  8. Change in 25-hydroxy Vitamin D

    Time frame: Baseline and Month 3

    Assessed via blood test at a local Labcorp location

  9. Change in hs-CRP

    Time frame: Baseline and Month 3

    Assessed via blood test at a local Labcorp location

  10. Change in Homocysteine

    Time frame: Baseline and Month 3

    Assessed via blood test at a local Labcorp location

Secondary outcomes

  1. Change in Self-Reported Reproductive Health

    Time frame: Baseline, Month 1, Month 2, and Month 3

    Assessed via self-reported questionnaire

  2. Change in Self-Reported Energy

    Time frame: Baseline, Month 1, Month 2, and Month 3

    Assessed via self-reported questionnaire

  3. Change in Self-Reported Libido

    Time frame: Baseline, Month 1, Month 2, and Month 3

    Assessed via self-reported questionnaire

Sponsors and collaborators

Lead sponsor

WeNatal

Industry

Collaborators

  • Citruslabs

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 31, 2026
Registry last updated
Jul 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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