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Completed

NCT Number: NCT07742605

A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Performance

This study evaluates the effects of the Xula Herbs Mind Food supplement on cognitive performance in adults aged 25-70 who report difficulty concentrating, memory challenges, brain fog, and low productivity. The trial is a single-arm, open-label, virtual study conducted over 6 weeks in 35 participants.

Participants will use the test product three times daily (sprayed three times under the tongue, at least 30 minutes before a meal, and not after 6 pm) for the duration of the study. Cognitive performance will be assessed via a Cognitive Battery Test at Baseline and Week 6, and self-reported questionnaires will be completed at Baseline, Week 2, Week 4, and Week 6.

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Key information

Conditions

Cognitive Impairment Behavior Behavioral Symptoms Brain Fog Cognition Disorders Cognitive Dysfunction Cognitive Performance Difficulty Concentrating Fatigue Memory Difficulties Mental Clarity Mental Disorders Mental Fatigue Neurocognitive Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Citruslabs

Las Vegas, Nevada, 89118, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be male or female.
  • Be aged 25-70.
  • Anyone experiencing issues with all of the following over the past four weeks: difficulty concentrating or low mental sharpness
  • difficulty with memory
  • experiences of brain fog or lack of mental clarity
  • feeling of low productivity.
  • Willing to refrain from taking any new products, over-the-counter medications, or supplements that may affect cognitive ability during the test period.
  • If taking any products, over-the-counter medications, or supplements that may affect cognitive ability, has been doing so consistently for at least three months and is willing to maintain this routine for the duration of the study.
  • Anyone who is generally healthy - does not live with any uncontrolled chronic disease.

Exclusion criteria

  • Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders.
  • Anyone with any allergies or sensitivities to any of the study product ingredients.
  • Anyone who is pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period).
  • Anyone unwilling to follow the study protocol.
  • Anyone diagnosed with a neurodegenerative condition.
  • Anyone taking an anticoagulant (also commonly referred to as a blood thinner) prescription medication.
  • Anyone with liver disease or kidney disease.
  • Anyone taking hormonal birth control or contraceptives.
  • Anyone with a history of substance abuse.
  • Anyone who drinks heavily (8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men).
  • Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration.

Treatment and study plan

Xula Herbs Mind Food Supplement

Dietary Supplement

All 35 participants receive the Xula Herbs Mind Food supplement taken three times daily by spraying three times under the tongue, at least 30 minutes before a meal and not after 6 pm, for 6 weeks

Primary outcomes

  1. Change in Cognitive Battery Test Score (Polygons)

    Time frame: Baseline and Week 6

    Change in performance on the Polygons timed processing test, measuring the brain's ability to sort and clarify information and judge the correct response, assessed via the Cognitive Battery Test

  2. Change in Cognitive Battery Test Score (Double Trouble)

    Time frame: Baseline and Week 6

    Change in performance on the Double Trouble timed test, measuring selective attention and processing speed based on the Stroop paradigm, assessed via the Cognitive Battery Test

  3. Change in Cognitive Battery Test Score (Feature Match)

    Time frame: Baseline and Week 6

    Change in performance on the Feature Match timed focus and processing task, assessed via the Cognitive Battery Test

  4. Change in Cognitive Battery Test Score (Paired Associates)

    Time frame: Baseline and Week 6

    Change in performance on the Paired Associates memory task, measuring recall of sequences and locations of items in increasing quantity, assessed via the Cognitive Battery Test

  5. Change in Cognitive Battery Test Score (Digit Span)

    Time frame: Baseline and Week 6

    Change in performance on the Digit Span task, measuring short-term memory and attention by recalling displayed number sequences of increasing length, assessed via the Cognitive Battery Test

  6. Change in Cognitive Battery Test Score (Spatial Planning)

    Time frame: Baseline and Week 6

    Change in performance on the Spatial Planning timed task, measuring executive function and ability to reorganize numbers into correct order, assessed via the Cognitive Battery Test

Secondary outcomes

  1. Change in Self-Reported Mental Clarity

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported experiences of mental clarity assessed via self-report questionnaire

  2. Change in Self-Reported Focus

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported ability to focus and concentrate assessed via self-report questionnaire

  3. Change in Self-Reported Memory Function

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported memory function assessed via self-report questionnaire

  4. Change in Self-Reported Alertness

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported alertness assessed via self-report questionnaire

  5. Change in Self-Reported Mood

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported mood assessed via self-report questionnaire

  6. Change in Self-Reported Brain Fog

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Change in participant-reported experiences of brain fog assessed via self-report questionnaire

Sponsors and collaborators

Lead sponsor

Xula Wellness LLC

Industry

Collaborators

  • Citruslabs

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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