A Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Atrophic Rhinitis

Clinical trials of platelet rich plasma injection for regeneration of atropic nasal mucosa.

• Injection interval and follow-up duration

• Injection interval 2 weeks (upto total 3 consecutive injection)
• Follow-up duration: 6 months
• Observation items, clinical assessment items and evaluation method

• Access the nasal mucosal status using nasal speculum.
• Access the nasal mucociliary function using saccharin test (primary outcome; once per month).
• Fill in the nasal symptom scores using Nasal Obstruction Symptom Evaluation(NOSE) Instrument, Sino-Nasal outcome Test 20, and Visual analog scale (secondary outcome; once per month)
• The other atrophic rhinitis patients who did not want to perform platelet rich plasma injection

• Random allocation to saline nasal irrigation or saline nasal spray group
• Perform same observation items, clinical assessment items and evaluation method as well as platelet rich plasma injection group

Inclusion criteria

• Adults (>18 years)
• Complaint of atrophic rhinitis symptoms including nasal crusting, nasal burning sensation, and postnasal drip
• Atrophic rhinitis view on nasal endoscopic finding
• Patients who informed sufficient about other atrophic rhinitis treatment options including Young's operation, lubricants, or saline irrigation, but, want more other active treatment option.

Exclusion criteria

• Platelet related disorders
• Low serum platelet (<100,000/㎕)
• Other hematologic disorders
• Septicemia
• Take anticoagulant drugs