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Completed

NCT Number: NCT06525792

A Clinical Study on Ozone Autohemotherapy for the Treatment of Acute Ischemic Stroke

Clinical studies applying ozonated autohemotherapy to treat acute cerebrovascular diseases have validated the safety and efficacy of this treatment, as well as explored its mechanism of action.

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Key information

Conditions

Acute Ischemic Cerebrovascular Disease

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fifth Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Confirmed by cranial CT or MRI examination, first-ever stroke, hospital admission within <24 hours of symptom onset,
  • age >18 years,
  • NIHSS score between 4 and 15,
  • TOAST classification as large artery atherosclerosis,
  • complete clinical records, minimum follow-up period of ≥3 months post-discharge,
  • willingness to undergo brachial blood puncture treatment, and provision of informed consent

Exclusion criteria

  • other neurological disorders, cerebral infarction caused by vertebral-basilar artery disease, cardioembolic stroke, or large-vessel vasculitis, acute or chronic infectious diseases, autoimmune or hematologic disorders, malignant tumors, mental abnormalities, severe heart, liver, or kidney dysfunction, intracerebral hemorrhage, and craniocerebral surgery history.
  • Contraindications for ozone therapy included hyperthyroidism, favism, severe coagulation disorders, and abnormal puncture site barriers

Treatment and study plan

Oxygen

Procedure

Oxygen and standard therapy were given

Ozone

Procedure

Ozone and standard therapy were given

standard therapy

Procedure

Best standard of care

Primary outcomes

  1. The expression of SOD(Superoxide dismutase)

    Time frame: 7 days

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Zhengzhou University

Other

Registry information

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Jul 29, 2024
Registry last updated
Jul 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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