A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome

Inclusion criteria

• Diagnosis of RA, classified by American Rheumatism Association 1987 revised criteria.
• According with the Zheng diagnosis of Traditional Chinese Medicine.
• age from 18 to 65 years.
• For patients currently receiving non-steroidal anti-inflammatory drugs (NSAIDs): Treatment at a stable dose during last 4 weeks prior to screening，or Patients do not take NSAIDs at least 1 weeks prior to screening.
• Patients not taking DMARDs at least 4 weeks prior to screening.
• Patients taking corticosteroids (≤15mg prednisone or Equivalent) ≥4 weeks before entering the trial.
• Patients agree to participate in this study and sign the informed consent form.

Exclusion criteria

• Patients have received intra-articular or systemic corticosteroid injection within 4 weeks of screening.
• Patients have high disease activity (DAS28-3 scores> 5.1).
• Patients have diagnosed any other chronic inflammatory disease or connective tissue disease like sicca syndrome（SS）, systemic lupus erythematosus (SLE)etc;
• Patients with sever diseases in Cardiovascular, brain, lung, liver, kidney and hematopoietic system ;
• Patients who are pregnant or nursing mothers or Psychiatric patients.
• Patients with active gastroduodenal ulcer or gastritis which caused by long-term use of NSAIDs;
• The patient who has known hypersensitivity to trial medicine .
• Patients have participated in other clinical trials within 4 weeks of screening.