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NCT Number: NCT07472582

A Chatbot to Reduce Chemsex and HIV-related Risk Behaviors Among Men Who Have Sex With Men

The goal of this clinical trial is to investigate whether receiving chatbot-delivered stage-of-change-tailored online interventions is effective in reducing chemsex among men who have sex with men in Hong Kong. The main question it aims to answer is:

Does chatbot-delivered stage-of-changed online interventions reduce chemsex among men who have sex with men

Eligible participants will be randomly assigned to either the intervention or the control group. The control group will watch one online video introducing chemsex-related knowledge and harm reduction skills per week for 12 weeks. On top of the interventions received by the control group, participants in the intervention group will have access to a chatbot during the 12-week intervention period. The chatbot will deliver 12 weekly episodes of interventions tailored to once's current stage-of-change related to chemsex. The chatbot will also address questions related to chemsex during the intervention period.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hong Kong men aged at least 18 years
  • Able to understand Cantonese
  • Had anal intercourse with at least one man within the past six months
  • Willingness to provide contact information for follow-up
  • Having access to WhatsApp

Exclusion criteria

  • Self-reported a diagnosis of schizophrenia or bipolar disorder

Treatment and study plan

Chatbot-delivered online interventions and online videos

Behavioral

Participants will watch one online video introducing chemsex-related knowledge and harm reduction skills per week for 12 weeks. The chatbot will deliver 12 weekly episodes of interventions tailored to once's current stage-of-change related to chemsex. The chatbot will also address questions related to chemsex during the intervention period.

Online videos only

Behavioral

Participants will watch one online video introducing chemsex-related knowledge and harm reduction skills per week for 12 weeks.

Primary outcomes

  1. Presence of chemsex in the past 3 months

    Time frame: Baseline, after completion of the 12-week intervention (Month 3 or Week 12), and 3 months after completion of the 12-week intervention (Month 6)

    Presence of chemsex will be measured by a validated questionnaire. Chemsex is defined as the use of any of the following psychoactive substances before or during sexual intercourse: ketamine, methamphetamine, cocaine, cannabis, ecstasy, Dormicum/Halcion/Erimin 5/nonprescription hypnotic drugs, heroin, cough suppressant (not for curing cough), amyl nitrite (popper), GHB/GBL, 5-methoxy-N, N-diisopropyltryptamine (Foxy), and mephedrone. Participants will be asked whether they had used any of the aforementioned psychoactive substances before or during sexual intercourse in the past 3 months at baseline, after completion of the 12-week intervention (Month 3 or Week 12), and 3 months after completion of the 12-week intervention (Month 6)

Study contacts

Contact information is provided by the study sponsor or research team.

Zixin Wang, PhD

CONTACT

[email protected]

+852 22528474

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Official study title

A Chatbot to Reduce Chemsex and HIV-related Risk Behaviors Among Men Who Have Sex With Men: a Pilot Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 16, 2026
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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