Skip to main content
OpenTrials
Completed

NCT Number: NCT07841782

Comparison of Local Infiltration Anesthesia and Superficial Cervical Plexus Block in Ultrasound-Guided Internal Jugular Vein Catheterization: Efficacy, Duration, and Local Anesthetic Volume - A Randomized Controlled Trial

Internal jugular vein (IJV) catheterization is a common invasive procedure performed under ultrasound (USG) guidance. Providing effective analgesia during the procedure is essential for patient comfort. This prospective, randomized controlled study aims to compare the clinical efficacy, onset time, required local anesthetic volume, and hemodynamic stability between ultrasound-guided local infiltration anesthesia (LIA) and ultrasound-guided superficial cervical plexus block (SCPB) using different volumes (2 mL, 5 mL, and 10 mL of 1% lidocaine) in patients undergoing IJV catheterization.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Catheterization, Central Venous Internal Jugular Vein Cannulation Neurologic Manifestations Pain Pain, Procedural Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

kayseri City Hospital Department of Anesthesiology and Reanimation

Kayseri, 38080, Turkey (Türkiye)

About this study

Central venous catheterization (CVC) is a widely used invasive procedure in critically ill and high-risk surgical patients for fluid resuscitation, hemodynamic monitoring, continuous infusion of vasoactive or venosclerotic drugs, and hemodialysis/hemofiltration. Among available vascular access sites, internal jugular vein (IJV) cannulation is the most commonly preferred route. However, awake patients undergoing IJV catheterization often experience significant pain and distress, which may negatively impact hemodynamic stability, patient comfort, and procedural success.

Although local infiltration anesthesia (LIA) is traditionally used to provide analgesia during IJV catheterization, it frequently falls short of providing optimal pain control. Ultrasound-guided regional anesthesia techniques, such as superficial cervical plexus block (SCPB), have emerged as effective alternatives for procedures involving the anterolateral neck region.

While both LIA and SCPB are utilized in clinical practice, there is a lack of prospective randomized literature directly comparing different local anesthetic volumes, onset times, and overall clinical efficacy between these two approaches. This prospective, randomized controlled trial aims to evaluate and compare ultrasound-guided LIA and SCPB in terms of anesthetic efficacy, onset time, required local anesthetic volume, and hemodynamic stability in patients undergoing IJV catheterization.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged between 18 and 80 years

American Society of Anesthesiologists (ASA) physical status I-III

Glasgow Coma Scale (GCS) score between 13 and 15

Patients scheduled for elective or semi-elective ultrasound-guided internal jugular vein catheterization

Patients who are literate, capable of effective communication, and provide written informed consent

Exclusion criteria

  • Glasgow Coma Scale (GCS) score < 13

Age < 18 years or > 80 years

ASA physical status IV or higher

Internal jugular vein catheterization performed under general anesthesia

Internal jugular vein catheterization performed under emergency conditions

Distorted head and neck anatomy preventing adequate ultrasound visualization for the block

Arterial puncture on the first needle insertion attempt

Illiterate patients or patients unable to establish effective communication to evaluate pain scores

Known allergy or hypersensitivity to local anesthetics

Treatment and study plan

Lidocaine HCl 1%

Drug

Administration of 1% lidocaine hydrochloride either via ultrasound-guided superficial cervical plexus block (at 2 mL, 5 mL, or 10 mL volumes) or via subcutaneous local infiltration (10 mL) prior to internal jugular vein catheterization.

Other names: LİDON %2 (diluted %1)

Primary outcomes

  1. Time to Effective Block Onset Across Different Local Anesthetic Volumes

    Time frame: Evaluated every 5 seconds, up to 5 minutes post-injection.

    Time elapsed (in seconds) from injection completion until effective analgesia is achieved (defined as an NRS score ≤ 2 via pin-prick test every 5 seconds), evaluating whether lower volumes of SCPB (2 mL and 5 mL) achieve effective block onset in a comparable timeframe to higher volume SCPB (10 mL) and standard LIA (10 mL).

  2. Time to Effective Block Onset Across Different Local Anesthetic Volumes

    Time frame: Evaluated every 5 seconds, up to 5 minutes post-injection

    Time elapsed (in seconds) from injection completion until effective analgesia is achieved (defined as an NRS score ≤ 2 via pin-prick test every 5 seconds), evaluating whether lower volumes of SCPB (2 mL and 5 mL) achieve effective block onset in a comparable timeframe to higher volume SCPB (10 mL) and standard LIA (10 mL).

Secondary outcomes

  1. Pain Intensity Across Procedural Stages (NRS Scores)

    Time frame: At baseline, during infiltration/block injection, during initial needle insertion, and during catheter placement.

    Evaluation of pain intensity using the Numerical Rating Scale (NRS, 0 = no pain to 10 = worst pain) to compare whether low-volume SCPB provides comparable pain control to high-volume SCPB and LIA across different procedural steps.

Interested in participating?

Completed

Looking for future studies?

Notify Me

Sponsors and collaborators

Lead sponsor

Kayseri City Hospital

Other Gov

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 25, 2026
Registry last updated
Sep 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.