Skip to main content
OpenTrials
Completed

NCT Number: NCT07840131

Anti-microbial Effect of Acacia Arabica Extract on Gingival and Periodontal Health of Dental Patients

This randomized clinical pilot study evaluated the short-term effects of Acacia arabica mouth rinse and paste as adjuncts to conventional oral hygiene in adults with plaque-induced gingivitis. Thirty systemically healthy participants aged 18-42 years were randomly allocated into three groups: a control group receiving conventional oral hygiene measures, an Acacia arabica mouth rinse group, and an Acacia arabica paste group. All participants received professional plaque removal and standardized oral hygiene instructions at baseline. Participants in the intervention groups additionally used either the Acacia arabica mouth rinse or paste twice daily for four weeks. Clinical assessments were performed at baseline, 2 weeks, and 4 weeks. The study evaluated changes in plaque index, gingival index, bleeding on probing, and salivary pH. The study aimed to determine whether Acacia arabica formulations could provide additional short-term benefits in plaque and gingival inflammation control compared with conventional oral hygiene measures alone.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Gingival and Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Umm AlQuar University Dental Hospital

Mecca, Saudi Arabia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-42 years.
  • Diagnosis of plaque-induced gingivitis.
  • Presence of gingival inflammation without clinical attachment loss or -radiographic evidence of alveolar bone loss.
  • Presence of a minimum of 15 natural teeth per arch.
  • Willingness to participate and provide written informed consent.

Exclusion criteria

  • Systemic diseases or medical conditions that may affect periodontal health.
  • Recent use of antibiotics or anti-inflammatory medications.
  • Presence of fixed orthodontic appliances/wires.
  • Current smoking.
  • Pregnancy or lactation.
  • Known allergy or hypersensitivity to herbal products.

Treatment and study plan

Acacia arabica Mouth Rinse

Other

the rinse as 1 g extract/10 mL distilled water

acacia arabica paste

Other

a pea-sized amount of Acacia arabica paste (Gumtone® gel)

Primary outcomes

  1. Change in Gingival Index (GI)

    Time frame: Baseline, 2 weeks, and 4 weeks

    Gingival inflammation was assessed using the Gingival Index at baseline, 2 weeks, and 4 weeks. The index was used to evaluate changes in the severity of gingival inflammation during the intervention period. Lower scores indicate less gingival inflammation and better gingival health.

  2. Change in Plaque Index (PI)

    Time frame: Baseline, 2 weeks, and 4 weeks

    Plaque accumulation was assessed using the Plaque Index at baseline, 2 weeks, and 4 weeks. The index was used to quantify changes in dental plaque accumulation during the intervention period. Lower scores indicate less plaque accumulation and better plaque control.

Interested in participating?

Completed

Looking for future studies?

Notify Me

Sponsors and collaborators

Lead sponsor

Umm Al-Qura University

Other

Registry information

Official study title

Short-term Effects of Acacia Arabica Mouth Rinse and Paste on Plaque-induced Gingivitis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 24, 2026
Registry last updated
Sep 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.