A Comparative Study Evaluating the Impact of Intensive Dietary Care on Weight Change and Biological Parameters in Patients Who Underwent Surgery for Craniopharyngioma During the First Postoperative Year

Inclusion criteria

• Retrospective group:

• Male or female patients aged between 18 and 70 (outside this age range, the BMI criteria are different).
• Patients with craniopharyngioma who underwent initial craniopharyngioma resection surgery in Prof. Dufour's neurosurgery department at La Timone Hospital (APHM) between 1 January 2017 and 31 December 2021.
• Weight data available at 15 days, 3 months and 1 year after their initial surgery in the Electronic Patient Record (EPR).
• Patient informed and not opposed to the reuse of their data.
• Prospective group:

• Male or female patients aged between 18 and 70 (outside this age range, the BMI criteria are different).
• Patients with craniopharyngioma in the immediate preoperative period of a first craniopharyngioma resection scheduled to be performed in Prof. Dufour's neurosurgery department at La Timone Hospital (APHM).
• Patients affiliated with or covered by a social security scheme.
• Patients who have signed a free, written and informed consent form.
• Patients who have scales at home and are able to weigh themselves.

Exclusion criteria

• - Retrospective group:

• Patients with type 1 diabetes due to possible weight variation linked to a potential imbalance in diabetes.
• Patients with a history of bariatric surgery, whose weight loss could be skewed by the surgical procedure (low food intake) and by changes in the secretion of the hormones leptin (satiety hormone) and ghrelin (hunger hormone), which are possible confounding factors.
• Patients with recurrent craniopharyngioma who have a history of craniopharyngioma surgery or radiotherapy treatment for this tumour. These patients may already have hypothalamic disorders, eating disorders or weight gain following the initial removal of the craniopharyngioma.
• Adult patients under guardianship or curatorship. Pregnant or breastfeeding women.
• Prospective group:

• Patients with memory disorders that prevent them from following dietary guidelines.
• Patients with type 1 diabetes due to possible weight variation linked to a potential imbalance in diabetes.
• Patients with a history of bariatric surgery, whose weight loss could be skewed by the surgical procedure (low food intake) and by changes in the secretion of the hormones leptin (satiety hormone) and ghrelin (hunger hormone), which are possible confounding factors.
• Patients with recurrent craniopharyngioma who have a history of craniopharyngioma surgery or radiotherapy treatment for this tumour. These patients may already have hypothalamic disorders, eating disorders or weight gain following the initial removal of the craniopharyngioma.
• Adult patients under guardianship or curatorship.
• Pregnant or breastfeeding women.
• Pregnancy (self-reported) or breastfeeding and all other categories of persons benefiting from special protection under the French Public Health Code (CSP): patients under legal protection, patients hospitalised without consent, patients admitted to social or health facilities for care and not for research, and patients in emergency situations.
• Patients unable to give informed consent or who refuse to participate in the study.

Patient already participating in an interventional study on craniopharyngioma.