Brain Heath Service for Prevention of AD

The aim of the program to serve as a prototype for future preventive program for AD in the region. The program will recruit elderly participants. Cognitive assessment and lifestyle questionnaire will be performed with each participant to investigator their risk factor associate with AD.

The program will offer medical referral and/or educational program(s) (e.g. tailor-made multidomain preventive measures plan, education talks) for participants who might have possible early AD or with high risk of AD

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Key information

Conditions

Alzheimer Cognition Disorders Cognitive Dysfunction Cognitive Unimpaired Mental Disorders Mild Cognitive Impairment Neurocognitive Disorders

Age range

55 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Epidemiological studies over the past few decades demonstrate that AD is associated with multiple modifiable risk factors, including cardiovascular risk factors, level of physical and cognitively stimulating or social activities, and dietary pattern. Recent large scale randomized controlled clinical trials show that single- or multi-domain lifestyle intervention and control in cardiovascular risk factors can slow down cognitive decline among subjects with early AD who have suboptimal control in AD modifiable risk factors.

This study aims to identify subjects with possible early AD, to investigate the control in AD modifiable risk factors among subjects with early AD, and to implement tailor-made preventive measures among early AD subjects with suboptimal control in risk factors.

Through the BEAT AD program, knowledge on preventive measures of AD can be promoted around Hong Kong.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1. Hong Kong citizens, between 55 - 80 years old.

Exclusion criteria

1. No known diagnosis of dementia or other diseases that may affect cognition, e.g., stroke, Parkinson's disease, brain infection, major head injury, major depression, obstructive sleep apnea, alcoholism (e.g., daily > 2 standard drinks for male and > 1 standard drinks for woman).
2. Subject who cannot understand Cantonese

Treatment and study plan

medical referral and/or educational programs

Behavioral

tailor-made multidomain preventive measures plan about diet, exercises, cognitive stimulation

Primary outcomes

Identification of possible early AD

Time frame: At baseline

Using MoCA and retinal Image AD Index to screening participants who have high risk of Alzheimer's Disease

Secondary outcomes

Investigation of the control in AD modifiable risk factors

Time frame: At baseline

Using the brain health scores to identify AD modifiable risk factors: (a) cardiovascular risk factors, (b) level of physical activity, (c) level of cognitively stimulating/social activities (CSA)
Implementation of AD preventive measures

Time frame: End of educational program(s) approximately at 12 months and 24 months

Base on the result of brain health score, tailor-made preventive measures among early AD subjects with suboptimal control in risk factors. Compare the results of brain health score after completion of health educational programs. Programs end time varies as they are tailor-made; yet evaluations will be done at 12 month and 24 months after baseline evaluation.

Interested in participating?

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Trial opening soon.

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Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Acronym: BEAT AD

Important dates

Study start: 2026
Primary completion: 2032
Study completion: 2033
First posted: Sep 22, 2026
Registry last updated: Sep 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not yet recruiting