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Completed

NCT Number: NCT07834294

Ventilation During CPR and Return of Spontaneous Circulation

During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured. This study examined whether the amount and rate of air delivered during CPR were related to the heart restarting its own circulation, called return of spontaneous circulation (ROSC).

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Key information

Conditions

Cardiac Arrest (CA) Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rush University Medical Center

Chicago, Illinois, 60612, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult subjects 18 years and older
  • Admitted to any area of the hospital, including the emergency department
  • Receiving manual ventilation by mask or artificial airway (laryngeal mask airway, endotracheal tube, or tracheostomy tube)
  • Cardiac arrest requiring CPR, including chest compressions

Exclusion criteria

  • anyone under 18 years of age

Treatment and study plan

Primary outcomes

  1. Number of Participants Who Achieved Return of Spontaneous Circulation (ROSC)

    Time frame: At the end of the monitored resuscitation event (Day 1).

    ROSC status was obtained from the medical record for the monitored resuscitation event and recorded as a binary outcome (yes/no). The number and percentage of participants with documented ROSC will be reported.

Sponsors and collaborators

Lead sponsor

Rush University Medical Center

Other

Collaborators

  • Hospital Civil Fray Antonio Alcalde
  • University of Maryland, Baltimore

Registry information

Official study title

Delivered Ventilation During Cardiopulmonary Resuscitation and Its Association With Return of Spontaneous Circulation: A Multicenter Observational Study

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Sep 22, 2026
Registry last updated
Sep 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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