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NCT Number: NCT07833982

Efficacy of an Integrated Psychological Interventions Combined With Ar_Rahman Listening for Reducing Psychological Distress and Enhancing Hope and Quality of Life Among Cancer Patients: A Randomized Controlled Trial

This is a randomized control trial(RCT ID:25142101) to evaluate the efficacy of psychological intervention combined with listening to surah Ar- RAhman for reducing psychological distress and improving cancer patients' hope and overall QOL compare to standard care. participants will be randomly assigned to two groups: intervention group will receive 14-sessions based manualized psychotherapy plus daily listening to surah Ar- rehman for 12 weeks, and control group will receive standard care .psychological distress will be measured with DASS-21, Quality of Life (QLQ-C30) for assessing Quality of life and Adult hope scale for assessing hope before and after the intervention.

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Key information

Conditions

Psychological Distress (Depression, Anxiety and Stress) Cancer Anxiety Disorders Behavior Behavioral Symptoms Depression Mental Disorders Neoplasms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Oncology department, IMPS, Noori & Shia International Hospital

Islamabad, 44000, Pakistan

About this study

this is a two- arm parallel randomized control trial. Background: psychological distress is common in cancer patients and affects treatment outcomes. spiritual and religious interventions, particularly, listening to QURAN recitation(Surah Ar Rahman), have shown potential to reduce anxiety and depression giving hope anf improving overall QOL.

objective: To determine the effectiveness of psychological intervention combined with Surah Ar Rahman listening in reducing psychological distress and enhancing hope and Quality of Life in cancer patients Methods: approximately 60 adults cancer patients will be recruited and randomized(1:1) into intervention and control groups. intervention group: 8 weekly psychological counseling session (30-45 min) based on supportive psychotherapy and CBT techniques plus listening to surah Ar Rahman recitation by Qari Abdul Basit (20 min daily). control group : Standard medical care and general information. assessment at pre and post intervention .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion Criteria
  • Aged 18 years or older
  • Have a confirmed diagnosis of cancer stage I and II will be included to obtain a relatively comparable clinical population and reduce variability associated with advanced disease and palliative care needs.
  • Are currently receiving or have received cancer-related treatment, such as chemotherapy, radiotherapy, surgery, immunotherapy, or other oncological treatment.
  • Education level will be matric atleast
  • Muslim patients
  • Able to communicate and provide consent

Exclusion criteria

  • • Severe psychiatric disorders
  • Cognitive impairment
  • Hearing impairments preventing audio participation
  • Physically unfit for this study's interventions (for example who are bed-bonded or too weak to engage in the study interventions)

Treatment and study plan

supportive psychotherapy plus QURAN recitation9Surah Ar -Rahman

Behavioral

participants in experimental group will receive 12 week psychological intervention : weekly 30-45 min counseling based on supportive therapy plus daily listening to Surah Ar Rahman recitation ( Qari Abdul Basit , 20 min ) via audio player, participants will be provided audio and intructed to listen daily and maintain a log.

Primary outcomes

  1. psychological distress (DASS-21)

    Time frame: baseline and 12 weeks post intervention

    Psychological distress will be measured using DASS-21, a 21 item self-report instrument with 3 subscales: Depression (7 items) Anxiety(7 items) and stress(7 items). each item is scored on 0-3 Likert scale. total score range is 0-63, Scores of each subscale are categorized into five severity ranges: Normal, mild, moderate, severe and extremely severe. For depression normal range(0-9), mild(10-13), Moderate(14-20), Severe(21-27), Extremely severe(28+), for anxiety normal range(0-7), mild(8-9), Moderate(10-14), Severe(15-19), Extremely severe(20+),for stress normal range(0-14), mild(15-18), Moderate(19-25), Severe(26-33), Extremely severe(34+) While the scores do not provide a functional diagnosis, they indicate the potential presence of depression, anxiety, and stress

Secondary outcomes

  1. Quality of Life -EORTC QLQ-C30

    Time frame: Baseline and 12 week post-intervention

    Quality of life will be measured using European Organization for Research and treatment of Cancer Quality of life Questionnaire(EORTC-QLQ-C30) Version 3.0. it is 30-item questionnaire composed of 5 functional scales, 3 symptoms scales, a global health status scale and 6 single items. scores are transformed to 0-100 scale. higher score in functioning and global QoL indicates better QOL, higher score in symptoms indicates worse symptoms

  2. Adult Hope scale(AHS)

    Time frame: baseline and 12 weeks post intervention

    hope will be measured using Adult hope scale(Snyder et al.,1991). it is 12-items scale with 4 agency items , 4 pathways items, and 4 distractors. items are scored on an 8-point Likert scale from 1- definitely False to 8= definitely true. total score range is 8-64. excluding distractors. higher score indicates higher level of hope

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Shaheed Zulfikar Ali Bhutto Institute of Science and Technology (SZABIST) University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 22, 2026
Registry last updated
Sep 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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