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NCT Number: NCT07832968

Mulligan Technique Versus Proprioceptive Training in Cervicogenic Headache

This study will be conducted to compare the effectiveness of mulligan versus proprioceptive training on pain severity, headache disability, flexion rotation test, pain threshold, cervical joint position error in patients with cervicogenic headache.

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Outpatient clinic of faculty of physical therapy Suez Canal university

Ismailia, Egypt

About this study

Cervicogenic headache (CGH) is a type of headache, and it occurs commonly due to neck dysfunctions. Many studies found positive association between the neck dysfunction and CGH. The prevalence of this problem is more common in women than men. Headache disorders are classified as primary, such as migraine or tension-type headache, or secondary, such as CGH. The one-year prevalence of CGH in the adult population varies between 0.2 and 2.2%.

It is severely impacts the general public, burdening public health and putting pressure on the local economy and community.

The International Classification of Headache Disorders (ICHD BETA 3) defined cervicogenic headache as "Headache caused by a disorder of the cervical spine and its component bony, disc and/or soft tissue elements, usually but not always accompanied by neck pain.

No drugs are effective for cervicogenic headache. Studies showed that treatment with manual therapy, specific exercises, or manual therapy plus exercises was significantly more effective at reducing headache frequency and intensity than was no treatment. Manual therapy alone, however, was not more effective than exercises alone, and combining the two interventions did not achieve better outcomes than either intervention alone. About 76% of patients achieved a more than 50% decrease in headache frequency and 35% achieved complete relief at the 7-week follow-up. At 12 months, 72% had a more than 50% decrease in headache frequency, but the proportion that had complete relief was not reported.

A recent systematic review concluded that manual therapy may be effective in the short term and neck exercise in the long term in treating adults with cervicogenic headache.

A popular method for mobilizing joints is the Mulligan Mobilization Technique (MMT), in which the patient moves actively as the therapist slides the affected joint. Efficacy of MMT has been proven in patients experiencing acute to subacute CGH for both short and long-term periods.

There is a link between proprioceptive afferent information and the ability to maintain body posture and good balance. Patients with neck pain have reduced proprioceptive abilities and balance training can improve deficits in proprioception and balance.

A correlation was seen between CGH and a rise in cervical reposition error as well as restricted range of motion as compared to healthy individuals. Patients with CGH should have their rehabilitation programs take these effects into account.

A case report shows that we can effectively enhance overall balance control when we combine balance training with conventional manual therapy methods for the treatment of cervicogenic headache.

Despite studies demonstrating the effectiveness of balance training regimens for cervicogenic dizziness, there is no studies done on patient with CGH except one case report and it seems to be effective. there is no current literature addressing the addition of a proprioceptive training added to mulligan mobilization for patients with cervicogenic headache. Therefore, the aim of this case study was to identify if proprioceptive training exercise in addition to mulligan mobilization had an impact on the headache frequency, pain, disability and overall quality of life in a patient with CGH.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CGH pain intensity between 3 and 8 on 10-point pain scale.
  • CGH due to cervical spine dysfunction.
  • Reduced cervical motion.
  • Neck pain followed by headache.
  • Unilateral pain starting in the neck and radiating to the frontotemporal region.
  • Reproduction of the headache on palpation of the upper cervical spine (C0 to C3).

Exclusion criteria

  • Participants with other types of headache (migraine).
  • Headache due to other causes (sinus, tumor, neural, or temporomandibular joint issues), and any type of physical therapy treatment in the past three months.
  • Any contraindications to manual and manipulative therapy (fracture, instability, osteoporosis, arthropathy, or neural symptoms).
  • Using analgesics or corticosteroids.
  • Metastasis.
  • Cardiac conditions (stroke, hypertension, or syncope).
  • Neurological conditions (radiculopathy, myelopathy, or disc problems).
  • Spinal cord problem.
  • Previous brain and spinal cord surgery.

Treatment and study plan

Mulligan Technique

Other

Mulligan Mobilization Technique will include Headache SNAG, Reverse Headache SNAG, and C1-C2 SNAG rotation. All techniques will be performed with the participant sitting in an erect posture. Headache SNAG and Reverse Headache SNAG will be applied at C2 for 10-30 seconds, with a maximum of 10 repetitions. C1-C2 SNAG rotation will be performed toward the restricted side for 10 repetitions with end-range overpressure and 30 seconds of rest between repetitions. The intervention will be administered in addition to the conventional physical therapy program for 12 sessions, 3 sessions per week for 4 weeks.

Proprioceptive training

Other

Proprioceptive training will include head relocation practice, cervical joint position retraining, and oculomotor exercises. Joint position sense will be trained using a head-mounted laser pointer with head movements and relocation to the neutral position, progressing from eyes open to eyes closed. Cervical joint position retraining will include tracing patterns with the laser. Oculomotor training will include eye-follow, saccades, gaze stability, and eye-head coordination exercises, with progression by increasing movement speed and range and modifying visual targets. The intervention will be administered in addition to the conventional physical therapy program for 12 sessions, 3 sessions per week for 4 weeks.

Conventional physical therapy program

Other

The conventional physical therapy program will include hot pack application for 10 minutes, therapeutic ultrasound for 5 minutes on each side at an intensity of 1-1.5 W/cm² over the trapezius, upper cervical, and occipitovertebral regions, and low-load endurance exercises for the craniocervical and cervicoscapular muscles. The exercise program will include craniocervical flexion training using pressure biofeedback and scapular muscle endurance exercises. The conventional program will be administered to participants in both study arms.

Primary outcomes

  1. Pain Intensity

    Time frame: 4 weeks

    Pain intensity will be assessed using the Visual Analogue Scale (VAS). Participants will rate their pain intensity on a 10-cm scale, where 0 indicates no pain and 10 indicates maximum intolerable pain.

  2. Headache Impact

    Time frame: 4 weeks

    Headache impact will be assessed using the Arabic version of the Headache Impact Test-6 (HIT-6). The total score ranges from 36 to 78, with higher scores indicating a greater impact of headache on daily functioning.

  3. Right Cervical Flexion-Rotation Range of Motion

    Time frame: 4 weeks

    Right cervical flexion-rotation range of motion will be assessed using the Cervical Range of Motion (CROM) instrument during the Flexion-Rotation Test (FRT). Rotation will be measured in degrees for the right side.

  4. Left Cervical Flexion-Rotation Range of Motion

    Time frame: 4 weeks

    Left cervical flexion-rotation range of motion will be assessed using the Cervical Range of Motion (CROM) instrument during the Flexion-Rotation Test (FRT). Rotation will be measured in degrees for the left side.

  5. Pressure Pain Threshold

    Time frame: 4 weeks

    Pressure pain threshold (PPT) will be assessed using a digital algometer. Measurements will be obtained over the upper trapezius muscle, C2-C3 zygapophyseal joint, suboccipital muscles bilaterally, and tibialis anterior muscle area. The mean of three trials at each measurement site will be used for analysis.

Secondary outcomes

  1. Cervical Joint Position Error

    Time frame: 4 weeks

    Cervical proprioception will be assessed using the Cervical Joint Position Error Test (CJPET) with a head-mounted laser pointer. Participants will attempt to relocate the head to the neutral starting position without visual cues. Joint position error will be measured and converted to degrees using the formula: angle = tan-¹ [error distance/90 cm].

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 22, 2026
Registry last updated
Sep 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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