Skip to main content
OpenTrials
Not yet recruiting

NCT Number: NCT07831291

Childhood Obesity Risk Markers (MARIOBE)

Metabolic diseases, including childhood obesity, represent a major public health challenge. Studies in mice have identified transcriptomic markers in adipose tissue capable of predicting a predisposition to obesity prior to any weight gain. The MARIOBE project aims to translate this approach to young children (≤ 4 years old) in order to identify individual vulnerability to obesity at an early stage.

Not yet recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Obesity & Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

1 day–4 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

Location contact

Etienne Merlin

PRINCIPAL_INVESTIGATOR

Lise Laclautre

CONTACT

[email protected]

+33473754963

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Child scheduled for surgery allowing for the harvesting of adipose tissue.

Exclusion criteria

  • Child whose holders of parental authority are protected by law

Treatment and study plan

early transcriptomic markers

Other

during a scheduled surgery before the age of 4 years, collection of a blood sample (2.5 mL in a PAXgene tube) and two adipose tissue fragments, each measuring 5 mm x 5 mm x 5 mm.

tracking of weight and height curves from birth to age 6

Primary outcomes

  1. transcriptomic markers in children under 4 years of age that predict a predisposition to being overweight at age 6 (BMI > IOTF25).

    Time frame: perioperative

    Ranking of the discriminative capacity of adipocyte and blood transcripts before 4 years of age to predict the development of overweight (BMI > IOTF25) at age 6, using Partial Least Squares Discriminant Analysis (PLS-DA).

Secondary outcomes

  1. analyze weight trajectories

    Time frame: at age 6 years

    Selection and validation of transcriptomic markers for the development of a predictive score for the risk of overweight and obesity in children

  2. molecular and epigenetic mechanisms associated with the identified transcriptomic signatures.

    Time frame: at the time of blood ans adipose tissu sampling

    methylation profiles

  3. comparison of transcriptomic expression levels between blood and adipose tissue

    Time frame: perioperative

    percentage of common markers sampled from blood and adipose tissue

  4. develop a quantitative test based on digital PCR to define individual expression thresholds predictive of risk

    Time frame: at age 6 years

    Performance of the digital PCR test evaluated by the ability to discriminate weight trajectories (AUC of ROC curves).

Study contacts

Contact information is provided by the study sponsor or research team.

Lise Laclautre

CONTACT

[email protected]

+334754963

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Registry information

Official study title

Childhood Obesity Risk Markers

Acronym: MARIOBE

Important dates

Study start
2026
Primary completion
2036
Study completion
2036
First posted
Sep 21, 2026
Registry last updated
Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.