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NCT Number: NCT07830927

Early Neurological Outcome in Pediatric Encephalitis

This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.

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Key information

Conditions

Encephalitis Brain Diseases Central Nervous System Diseases Nervous System Diseases Neuroinflammatory Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

1 month–12 year

Sex eligibility

All sexes

Study type

Observational

About this study

Encephalitis in children carries a high risk of neurological sequelae. This observational study will include children aged 1 month to 12 years with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.

Baseline clinical, laboratory, neuroimaging, and EEG findings will be recorded. Early neurological outcome will be assessed at hospital discharge using the pediatric modified Rankin Scale (mRS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 1 month to 12 years
  • Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition
  • Written informed consent from parents or legal guardians

Exclusion criteria

  • Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness
  • Primary diagnosis of traumatic brain injury or cerebral malaria
  • Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode
  • Absence of documented neurologic outcome assessment

Treatment and study plan

Primary outcomes

  1. Functional neurological outcome at discharge

    Time frame: Up to 30 days

    Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome

Secondary outcomes

  1. Duration of hospital stay

    Time frame: Up to 30 days

    Length of hospital stay in days.

  2. Need for intensive care unit admission

    Time frame: Up to 30 days

    Number of children who require intensive care unit admission

  3. Need for nasogastric tube feeding at discharge

    Time frame: Up to 30 days

    Number of children who require nasogastric tube feeding at the time of hospital discharge

  4. Nosocomial infections

    Time frame: Up to 30 days

    Number of children who develop nosocomial infections during hospitalization

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Predictors of Early Neurological Outcome in Children With Encephalitis: A Prospective Study From Assiut University Children Hospital

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Sep 21, 2026
Registry last updated
Sep 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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