Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy

This study evaluated whether bilateral erector spinae plane block (ESPB) performed before abdominal hysterectomy could reduce postoperative pain and the development of chronic and neuropathic pain. Adult patients undergoing abdominal hysterectomy under general anesthesia were assigned to receive either bilateral ESPB with bupivacaine or standard perioperative analgesic management without ESPB. Postoperative pain was assessed during the early postoperative period and at 1 and 6 months after surgery. Chronic and neuropathic pain were evaluated at 1 and 6 months using validated pain assessment tools.

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Key information

Conditions

Postoperative Pain Chronic Postsurgical Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Necmettin Erbakan University Medical Faculty Hospital Konya, Türkiye

Konya, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged 18-65 years American Society of Anesthesiologists (ASA) physical status I-III Body mass index (BMI) <35 kg/m² Scheduled for elective total abdominal hysterectomy under general anesthesia Provided informed consent to participate in the study

Exclusion criteria

Decompensated heart failure Severe respiratory distress Renal failure Hepatic failure History of opioid addiction Current anticoagulant use or bleeding diathesis Refusal to participate in the study

Treatment and study plan

Bupivacaine

Drug

0.25% bupivacaine, 20 mL administered bilaterally as part of ultrasound-guided erector spinae plane block at T8-T9.

Standard Perioperative Analgesia

Other

Participants received standard perioperative analgesic management according to the routine institutional protocol, without erector spinae plane block.

Primary outcomes

Chronic postoperative pain severity at 6 months

Time frame: 6 months after surgery

Chronic postoperative pain severity was assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst pain imaginable).

Sponsors and collaborators

Lead sponsor

Necmettin Erbakan University

Other

Registry information

Official study title

THE EFFECT OF ERECTOR SPINAE PLANE BLOCK PERFORMED IN ABDOMINAL HYSTERECTOMY ON ACUTE, CHRONIC POSTOPERATIVE, AND NEUROPATHIC PAIN: A RANDOMIZED CONTROLLED PROSPECTIVE STUDY

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Sep 21, 2026
Registry last updated: Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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