Home-based Pulmonary Rehabilitation in Interstitial Lung Disease

King's-Brief Interstitial Lung Disease questionnaire: It is a validated brief health status questionnaire developed especially for patients with ILD. It contains 15 questions that evaluates the health status of patients in three different domains- breathlessness and activities, psychological and chest symptoms. The patient's responses are measured and finally expressed on a scale of 0-100 based on individual responses in each domain. The minimal clinically important difference is 5 points. It will be completed by the study subjects at baseline and 8 weeks.

Change in dyspnea will be assessed on modified Medical Research Council [mMRC] scale at the end of 8 weeks from randomization

Mean change in six-minute walk distance will be compared between the study groups at the end of 8 weeks from randomization. Six-minute walk test (6MWT) will be performed using American Thoracic Society guidelines

Mean change in EQ-5D-5L score will be compared between the study groups at the end of 8 weeks from randomization. EuroQol-5D-5L (EQ-5D-5L) questionnaire is a widely used standardized instrument designed to measure generic health-related quality of life (HRQoL). It evaluates five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each rated across five levels of severity. The responses are combined into a single health state index and complemented by a visual analogue scale (VAS) ranging from 0 (worst imaginable health) to 100 (best imaginable health). It is applicable across diseases and treatments and will be administered at baseline and 8 weeks.

Forced vital capacity will be assessed by spirometry. Spirometry will be performed according to the ATS/ERS guidelines using an ultrasonic flow sensor spirometer (NDD Medizintechnik AG, Zurich, Switzerland).

Number of adverse events will be recorded and compared between study groups. These will include disease progression, acute exacerbation, hospitalization, respiratory failure, death, excessive breathlessness, oxygen desaturation, chest pain, chest tightness, palpitations, presyncope/syncope, dizziness, light-headedness, excessive fatigue, weakness, or headache during or after exercise, musculoskeletal pain or injury, including muscle strain, joint pain, back pain, tendon injury, or sprain, exercise-related falls or loss of balance, particularly during stair climbing, squats, heel raises, or unsupported activities, exacerbation of cough or wheeze during exercise, delayed post-exercise symptoms, such as prolonged fatigue, myalgia, or breathlessness persisting for several hours, exercise intolerance requiring reduction or interruption of the prescribed programme.