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Completed

NCT Number: NCT07828925

Selective Axillary Dissection After Neoadjuvant Chemotherap Yin Patients With Lymphnode-positive Breast Cancer

The aim of this observational study is to collect data regarding the selective axillary dissection tecnique of lymphnode restaging after neoadjuvant chemotherapy in patients with Breast Cancer that is lymphonode positive at the time of the diagnosis.

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Key information

Conditions

Breast Cancer Female Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Radiology Department- Fondazione Policlinico Universitario A. Gemelli IRCCS

Roma, 00168, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age>= 18 years
  • Female sex
  • Diagnosis of Lymph Node- Positive (cN+) Breast Cancer through core needle biopsy, cT1-3 (multifocal too)
  • Absence of distant metastases (M0)
  • Patients that will undergo to NACT

Exclusion criteria

  • Previous diagnosis of Breast Cancer
  • Previous Breast and/or Axillary Surgery
  • Pregnancy
  • Inflammatory Breast Cancer (cT4)
  • Patients that will not undergo to NACT

Treatment and study plan

Primary outcomes

  1. Number of patients where the lymph node containing the clip does not match the sentinel lymph node

    Time frame: From enrolment until Surgery Time

    To verify the number Number of patients where the lymph node containing the clip does not match the sentinel

Secondary outcomes

  1. Number of Patients that will not undergo to Selective Axillary Dissection

    Time frame: From enrolment until Surgery Time

    To assess Number of Patients that will not undergo to Selective Axillary Dissection

  2. Number of preoperative correct identification of the lymph node with the clip

    Time frame: From enrolment until Surgery Time

    To assess the match between preoperative identification of the lymph node and the lymph node with clip at surgery time

Sponsors and collaborators

Lead sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Other

Registry information

Official study title

Selective Axillary Dissection After Neoadjuvant Chemotherapy in Patients With Lymphnode-positive Breast Cancer

Acronym: CLYP

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Sep 18, 2026
Registry last updated
Sep 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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