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NCT Number: NCT07827274

Combining Moderate Aerobic Exercise With Inspiratory Muscle Training for Dialysis Patients With Atrial

Statement of the problem:

Is there a difference between of inspiratory muscle training with aerobic exercise or inspiratory muscle training for hemodialysis patients with AF??

Purpose of the study:

To find out the effect of combined inspiratory muscle training with aerobic exercise OR inspiratorty muscle traiting for hemodialysis CKD patients with atrial fibrillation as regards The following outcomes:

1. medical state of patient (heart rate, blood pressure, oxygen saturation) 2. lab analysis (GFR, Serum creatinine, blood urea and nitrogen (BUN) and INR) 3. maximum Inspiratory pressure (MIP) 4. period, duration of dialysis 5. short form questionnaire(SF36) 6. modified Borg scale

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Key information

Conditions

Atrial Fibrillation (AF) Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients from both gender
With chronic kidney failure(GFR>30)
with atrial fibrillation
Unemployed living a sedentary lifestyle
Receive regular hemodialysis sessions at 2months ago
All of them have vascular access through arteriovenous fistula
Age range from 40-60 years
Fully understand purpose and procedure of study
Stable and have sufficient level of cognition and ability to understand instructions

Exclusion criteria

Patients who meet one of the following criteria will be excluded

Real difficulties with understanding and signing The written informed consent
Recent sequela of cerebrovascular accidents
Osteoarticular or musculoskeletal diseases
Un controlled systemic hypertension
Un controlled diabetes
Un stable angina
Fever
Infectious disease
Acute respiratory failure
Recent acute myocardial infarction
Peripheral vascular diseases

Treatment and study plan

inspiratoy muscle training

Device

intervention : (inspiratory muscle training) (inspiratory muscle training at 30% of maximal inspiratory pressure for20 minutes/ session, 3 days a week, for 3 months Each patient breathes through a separate mouthpiece. The resistance is adjusted 30% of maximum inspiratory pressure detected from maximum inspiratory pressure meter and is marked on the training device. A single training session consists of five sets, each contains five inspirations with total of twenty five breaths with one minute of recovery between each set. The resistance was adjusted every month at 30%of the new maximum pressura and if it remain the subject remain at the same level

Aerobic exercise +inspiratory muscle training

Device

b) Active phase:

Mode:moderte -intensity interval aerobic training (MIIT).
Intensity: With MODERTE intensity continous of 60 %of heart rate reserve (HRR) monitored by ECG and a 5-minute cool-down following exercise at intensity (30- 40%HR RESERVE) were carried out each time.

In addition, the exercise was performed in the first half of the dialysis session over a 3 months period for 3 sessions per week by cycling for 20 min at a moderate intensity(60%HR RESERVE) participants were trained to use stationary bicycle ergometer in a supine position for minimum of 30 minutes at each HD session.

The speed, load, and duration were gradually increased with change of mode (automatic and passive).

inspiratory muscle training)

Primary outcomes

6 minute walk test

Time frame: at the start of study and after intervention (3months)

6 minute walk test : (To detect functional capacity, carry out in a 20 -meter line along The passage way, The tape is placed every 30 meters

.patients are instructed to walk The longest possible distance in 6 minutes continuously, turning around at The final Mark without stopping. they are further instructed to walk as far as they can for 6minutes without running or jogging, covered distance in meters is measured at the end of the rest for analysis

Study contacts

Contact information is provided by the study sponsor or research team.

eman M abdallah, master degree

CONTACT

[email protected]

00201000665383

mahmoud I mahmoud, lecturer

CONTACT

[email protected]

00201142998414

Sponsors and collaborators

Lead sponsor

Beni-Suef University

Other

Registry information

Official study title

Antiremodelling Effect of Moderate Intensity Aerobic Combined With Inspiratory Muscle Trainings on Kidney Dialysis With Atrial Fibrillation

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Sep 18, 2026
Registry last updated: Sep 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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