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NCT Number: NCT07825896

Autogenous Sticky Bone Plus Platelet-rich Fibrin Membrane Versus Xenograft With Collagen Membrane for Posterior Atrophic Mandible

Background: Teeth loss in the posterior mandible initiates residual ridge resorption, this causes difficulty in implant placement so ridge augmentation must be done either simultaneous with implant placement or in a staged approach Aim: To evaluate the effect of autogenous sticky bone with PRF membrane and xenograft with collagen membrane with simultaneous implant placement clinically on primary and secondary implant stability, and radiographically on bucco-lingual width gain, bone density and crestal bone loss

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Key information

Conditions

Ridge Augmentation

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt

Alexandria, Azarita, 00203, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with missing posterior mandibular teeth.
  • Horizontal bone defect with width < 5.5 mm.
  • Adequate zone of keratinized tissue

Exclusion criteria

  • Presence of infection or periapical lesions in adjacent teeth.
  • Medically compromised patients with a condition that affects the procedure.
  • Insufficient inter-arch distance.
  • Bruxism or clenching.
  • Alcoholism.
  • Heavy Smokers.

Treatment and study plan

autogenous sticky bone + PRF membrane

Other

Patients in this group will be treated using autogenous sticky bone with PRF membrane.

Xenograft + collagen membrane

Other

Patients in this group will be treated using a xenograft with a collagen membrane.

Primary outcomes

  1. Change in implant stability

    Time frame: up to 6 months

    Implant stability will be recorded immediately after placement (1ry stability) and after 6 months (2ry stability ) by using osstell device. The result is presented in form of ISQ value from 1 to 100, the higher the ISQ the higher the stability of implant

  2. change in bucco-lingual bone thickness

    Time frame: up to 6 months

    All participants in the study will be advised to undergo CBCT before implant placement to measure bucco-lingual bone thickness, and again 7 days postoperatively and 6 months after implant placement to assess the following.

  3. change in marginal bone level

    Time frame: up to 9 months

    At buccal, lingual, mesial, and distal sites will be evaluated radiographically from the shoulder of the implant to the alveolar crest. The mean marginal bone loss after the placement of implants will be calculated by subtracting baseline value from the values obtained at 6 and 9 months post implant placement

  4. change in ridge width

    Time frame: up to 6 months

    Will be measured immediately and after 6 months, bone width will be measured for each implant at three levels (2, 5, and 10 mm from the alveolar crest) and the mean will be calculated for each implant at each time interval.

Secondary outcomes

  1. change in pain scores

    Time frame: up to 7 days

    Pain will be assessed for 7 days postoperatively using 10-point visual analouge scale (VAS). (0-1=None, 2-4=mild, 5-7=moderate, 8-10=severe ).

  2. change in edema scores

    Time frame: up to 7 days

    Edema will be assessed by a descriptive 4-point scale immediately post-operative, and at the 2nd,3rd,7th days postoperatively. Measured as follows: No inflammation = none. Intra oral swelling confined to the surgical field = mild. Extra oral swelling in the surgical zone =moderate. Extra oral swelling spreading beyond the surgical zone =intense.

  3. change in bone density

    Time frame: up to 6 months

    Will be measured at 6 points around the implant and a mean value will be calculated

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Autogenous Sticky Bone Plus Platelet-rich Fibrin Membrane Versus Xenograft With Collagen Membrane for Treatment of Posterior Atrophic Mandible (A Randomized Controlled Clinical Trial)

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 17, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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