Skip to main content
OpenTrials
Not yet recruiting

NCT Number: NCT07825675

EEG Abnormalities as Predictor of Outcome in Pediatric Encephalopathy

This prospective cohort study aims to evaluate the prognostic value of electroencephalographic (EEG) abnormalities in predicting poor clinical outcomes among children with encephalopathy admitted to Assiut University Children Hospital.

Not yet recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Encephalopathy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

1 month–18 year

Sex eligibility

All sexes

Study type

Observational

About this study

Pediatric encephalopathy has multiple etiologies and variable neurological outcomes. Early prognostic assessment is essential for clinical decision-making and family counseling. Electroencephalography (EEG) is a non-invasive tool that may help predict neurological outcome.

This prospective observational study will include children aged 1 month to 18 years with clinical diagnosis of encephalopathy. EEG will be performed within the first 48 hours of admission. Neurological outcome will be assessed at hospital discharge using the Pediatric Cerebral Performance Category (PCPC) scale. A PCPC score of 1-2 will be considered good outcome and a score of ≥3 will be considered poor outcome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 1 month to 18 years
  • Clinical diagnosis of encephalopathy with altered level of consciousness
  • EEG performed within the first 48 hours of admission
  • Written informed consent from parents or legal guardians

Exclusion criteria

  • Neonatal encephalopathy
  • Children with severe pre-existing neurological disability
  • Known epileptic patients
  • Incomplete clinical or EEG data

Treatment and study plan

Primary outcomes

  1. Poor neurological outcome at hospital discharge

    Time frame: at 30 days

    Proportion of children with poor neurological outcome defined as Pediatric Cerebral Performance Category (PCPC) score ≥3 at hospital discharge.

Secondary outcomes

  1. Frequency of EEG abnormalities

    Time frame: Within the first 48 hours of admission

    Proportion of children with specific EEG abnormalities (diffuse background slowing, background suppression, burst suppression, absent reactivity, low-voltage activity, or electrographic seizures) recorded within the first 48 hours of admission.

  2. Predictive performance of EEG abnormalities for poor outcome

    Time frame: at 30 days

    Sensitivity, specificity, and predictive values of specific EEG abnormalities for poor neurological outcome (PCPC ≥3) at hospital discharge.

  3. Mortality

    Time frame: at 30 days

    Proportion of children who die during hospital stay.

  4. Duration of PICU stay

    Time frame: at 30 days

    Length of stay in the pediatric intensive care unit in days.

Interested in participating?

Not yet recruiting

Trial opening soon.

Get Notified

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Electroencephalographic (EEG) Abnormalities as a Predictor of Poor Outcome in Pediatric Encephalopathy

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Sep 17, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.