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NCT Number: NCT07824908

Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy

The aim of this prospective, randomized study is to evaluate the effects of two different specimen extraction sites (periumbilical versus left lower quadrant) and the routine application of port-site local anesthesia infiltration on postoperative pain and complications in patients undergoing laparoscopic appendectomy for acute appendicitis."

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Key information

Conditions

Appendectomy, Laparoscopic Agnosia Appendicitis Appendicitis Acute Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Management Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gazi Yasargil Training and Research Hospital

Diyarbakır, Kayapınar, 21070, Turkey (Türkiye)

Location status: Recruiting

Location contact

Yunus YUKSEL

CONTACT

[email protected]

+905334367335

About this study

The purpose of this prospective, randomized clinical trial is to investigate the clinical impact of two different specimen extraction sites (periumbilical versus left lower quadrant) on postoperative pain. Additionally, the study evaluates the efficacy of routine preemptive local anesthesia infiltration at all trocar sites. Patients undergoing laparoscopic appendectomy are randomly allocated into four parallel groups based on the extraction site and the administration of local anesthesia. The primary objective is to compare local and regional pain scores at the extraction and non-extraction port sites, assessed via the Numeric Rating Scale (NRS) at the 2nd, 4th, 8th, 12th, and 24th postoperative hours. Secondary outcomes include total postoperative analgesic consumption, operative duration, length of hospital stay."

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years or older
  • Diagnosed with acute appendicitis
  • Scheduled for emergency laparoscopic appendectomy
  • Informed consent obtained

Exclusion criteria

  • Conversion to open surgery
  • Known allergy to local anesthetics
  • Cognitive impairment or inability to understand the NRS scoring system
  • Pregnancy

Treatment and study plan

Port-site local anesthesia infiltration

Drug

Infiltration of local anesthetic solution (bupivacaine) into the skin, subcutaneous tissue, and fascial layers of all trocar sites prior to closure

Port-Site Saline Infiltration (Placebo)

Other

Prior to wound closure, a total of 10 cc of %0.9 normal saline solution is infiltrated into the skin, subcutaneous tissues, and fascial layers of all trocar sites as a placebo control

Primary outcomes

  1. Postoperative Pain Score at the Specimen Extraction Site

    Time frame: Postoperative 8th hour.

    Evaluated using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst possible pain).

Secondary outcomes

  1. Postoperative Pain Scores at Subsequent Time Points

    Time frame: Postoperative 2th, 4th, 12th, and 24th hours.

    Postoperative regional pain assessed at the specimen extraction site and non-extraction port sites using the Numeric Rating Scale (NRS), which ranges from 0 (no pain) to 10 (worst possible pain)

  2. Total Postoperative Analgesic Consumption

    Time frame: Postoperative 24 hours

    The total amount of rescue analgesic medication (specifically the cumulative dose of tramadol/contramal required by the patient) administered during the first 24 hours after surgery.

  3. Length of Hospital Stay

    Time frame: From postoperative admission to the general surgery ward until hospital discharge.

    The total duration of the patient's hospitalization, measured from the time of admission to the general surgery ward post-surgery until the time of official hospital discharge.

  4. Operative Duration

    Time frame: From initial skin incision to final wound closure (intraoperatively).

    The total surgical duration, measured in minutes from the initial skin incision to final wound closure.

  5. Total Intraoperative Insufflation Gas Volume

    Time frame: From initiation of pneumoperitoneum until completion of the surgical procedure.

    The total volume of carbon dioxide gas used for pneumoperitoneum throughout the surgical procedure, recorded in liters from the insufflator device.

Sponsors and collaborators

Lead sponsor

YUNUS YÜKSEL

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 17, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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