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Recruiting

NCT Number: NCT07824648

Thermoregulatory Physiology of Menopausal Hot Flashes

This study is evaluating the effects of cooling on menopausal hot flashes in midlife women. Precise targeted cooling is provided to areas of the skin when a hot flash occurs.

Recruiting

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Key information

Age range

40 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

SRI International

Menlo Park, California, 94025-3453, United States

Location status: Recruiting

Location contact

Fiona Baker

CONTACT

[email protected]

6508593062

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female
  • Age range: 40 to 65 years and in menopausal transition or post-menopause;
  • At least 8 years of education to ensure adequate reading proficiency;
  • Primary language is English or Spanish.

Exclusion criteria

  • History of medical or neurological illness or trauma that would affect the central nervous system (e.g., stroke, multiple sclerosis, epilepsy);
  • Current severe medical conditions (e.g. Diabetes, cancer, cardiovascular disease, renal or hepatic disease, thyroid disorders);
  • History of schizophrenia and/or bipolar disorder;
  • Dependence or abuse of illicit substances in the past year;
  • Current use of hormone therapy or other treatments for hot flash symptoms

Treatment and study plan

Intervention C (Targeted skin cooling)

Other

Cooling targeted to the skin during a hot flash

Intervention B (Ambient cooling)

Other

Cooling of the room

Intervention A (Room temperature)

Other

Control condition (room temperature)

Primary outcomes

  1. Number of hot flashes

    Time frame: Across the ~5 hour experimental period in the lab

    Number of hot flashes, based on sternal skin conductance measurement

Sponsors and collaborators

Lead sponsor

SRI International

Industry

Collaborators

  • National Institute on Aging (NIA)
  • Stanford University

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 17, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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