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NCT Number: NCT07824245

Advancing Ethical Goals In Society Trial

The goal of this clinical trial is to make sure that the values of older persons aged 65 years or older with Alzheimer's Disease and Related Dementias (ADRD) or increased risk of mortality are known and respected, thereby reducing the burden of intrusive, unwanted medical interventions on their lives. The main aims of the study are:

* To assess the impact of our Advance Care Planning (ACP) Counselor Video Program on ACP documentation and receipt of goal-concordant care in a diverse sample of older adults with ADRD or other serious illness * To compare resuscitation preferences, hospice use, healthcare utilization and costs

Researchers will randomize participants into two groups. All participants will continue to receive routine care. Participants randomized to the Immediate-Start Intervention group will be offered the ACP Counselor Video Program during both Phase 1 and Phase 2. Participants randomized to the Routine Care/Delayed-Start Intervention group will receive routine care alone during Phase 1 and will be offered the ACP Counselor Video Program beginning in Phase 2. Each phase will last two years. Both groups will have access to the intervention during Phase 2.

During the intervention, participants will:

* Meet with ACP counselors * Watch ACP videos.

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Key information

Conditions

Advance Care Planning Alzheimer Disease Alzheimer's Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dartmouth Health, Lebanon, New Hampshire, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

as ascertained within a month of randomization

Age ≥65 years as of the cohort eligibility/index date
At least one qualifying ambulatory encounter during the 12-month assessment window
One of the following

Diagnosed with Alzheimer's Disease or Related Dementias (ADRD) based on a pre-specified ICD-10 code list, or
Estimated 1-year mortality risk of at least 20%, based on a prespecified health-system mortality-risk algorithm, or
Age 90 and above

Exclusion criteria

Patients receiving hospice or program of All-Inclusive Care for the Elderly (PACE)
Patients who primarily reside in a skilled nursing facility
Incarcerated patients

Treatment and study plan

ACP Counselor Video Program

Other

Participants will meet with ACP counselors to talk about their goals of care. Participants and surrogates will watch and discuss videos about ACP options with the ACP counselor.

Primary outcomes

Presence of qualifying ACP documentation by the end of Phase 1

Time frame: From randomization through the end of Phase 1 (24 months).

This outcome will be the percentage of participants with qualifying ACP documentation. Qualifying ACP documentation is defined as ACP documentation that is newly created or updated during Phase 1.
Occurrence of adjudicated goal-concordant care during the last 3 months of life

Time frame: Final 3 months of life among participants who die during Phase 1, up to 24 months after randomization.

This outcome is defined to be the percentage of decedents classified as having goal-concordant care.

Study contacts

Contact information is provided by the study sponsor or research team.

Carly Bridden

CONTACT

[email protected]

Diya Patel, Bachelors

CONTACT

[email protected]

774-218-6634

Sponsors and collaborators

Lead sponsor

Tufts Medical Center

Other

Collaborators

Dana-Farber Cancer Institute
Dartmouth-Hitchcock Medical Center
Emory University
Feinstein Institute for Medical Research
Mayo Clinic Arizona ADRC
National Institute on Aging (NIA)
Northern California Institute of Research and Education
Trustees of Dartmouth College
University of Colorado, Denver
Wake Forest University Health Sciences

Registry information

Official study title

ACP Educator Video Program to Promote Goal-Concordant Care in Older Patients and Those With Alzheimer's Disease and Related Dementias: Advancing Ethical Goals In Society (AEGIS)

Acronym: AEGIS

Important dates

Study start: 2027
Primary completion: 2029
Study completion: 2031
First posted: Sep 17, 2026
Registry last updated: Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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