NCT Number: NCT07824180
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure.
The study will compare patients treated before and after the new treatment approach is introduced in participating Swiss hospitals. Information on treatment, hospital admissions, complications and recurrence of diverticulitis will be collected. Patients will be followed for up to 24 months.
Trial opening soon.
Get Notified18 year and older
All sexes
Interventional
Not applicable
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
-.Alternative diagnosis explaining the participant's symptoms
A standardized treatment approach based on clinical findings, laboratory results, comorbidities, immunosuppression status, and CT findings is introduced to support treatment decisions in patients with acute uncomplicated diverticulitis. Depending on these factors, patients may be managed with or without antibiotics.
Time frame: Within 90 days after diagnosis
Treatment failure is defined as a composite outcome including progression to complicated diverticulitis requiring percutaneous abscess drainage or surgery, delayed initiation of antibiotics after initial management without antibiotics, or unplanned hospital admission following initial outpatient treatment.
Time frame: Within 90 days after diagnosis
Proportion of participants receiving antibiotics
Time frame: At the initial treatment decision
Proportion of participants whose management is consistent with the standardized treatment approach.
Time frame: At the initial treatment decision
Proportion of participants initially managed as outpatients versus inpatients.
Time frame: Within 30 days after diagnosis
Proportion of participants readmitted to hospital.
Time frame: Within 24 months after diagnosis
Proportion of participants experiencing recurrence of diverticulitis.
Contact information is provided by the study sponsor or research team.
Dimitri Christoforidis, MD
CONTACT
Elena Porro, Msc
CONTACT
Ente Ospedaliero Cantonale, Bellinzona
Other
From Guidelines to Real-world Practice: a Pragmatic Before and After Study on the Treatment of Acute Uncomplicated Diverticulitis (AUD) Based on a Risk Factor Driven Treatment Algorithm (AUD Management Algorithm Protocol)
Acronym: AUD
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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