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NCT Number: NCT07823439

Pattern and Surgical Outcome of Papillary Thyroid Cancer at Sohag University Hospitals

The aim of this study is to evaluate the clinicopathological pattern and surgical outcome of papillary thyroid carcinoma (PTC) at Sohag University Hospitals. This will help improve local risk stratification, optimize surgical decision-making, and guide future management strategies for patients with PTC in this region.

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Key information

About this study

Papillary thyroid carcinoma (PTC) is the most common histological subtype of thyroid cancer, representing about 80-85% of cases. This study is a case-series study with both retrospective (June 2023 - June 2026) and prospective (June 2026 - March 2027) components, conducted at the Department of General Surgery, Sohag University Hospitals.

All patients diagnosed with papillary thyroid carcinoma and managed at Sohag University Hospitals during the study period will be included. Data collection includes baseline demographic and clinical features, preoperative laboratory tests (thyroid function tests and serum calcium), neck ultrasonography findings (ACR TI-RADS category, nodule size, and lymph node assessment), fine-needle aspiration cytology (Bethesda System), surgical intervention types (hemithyroidectomy, total thyroidectomy, and neck dissection), final histopathological characteristics (tumor size, multifocality, lymphovascular invasion, extrathyroidal extension, and nodal status), and early postoperative complications (hypocalcemia, recurrent laryngeal nerve palsy, hematoma, seroma, and wound sepsis).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients diagnosed with papillary thyroid carcinoma and its variants managed at Sohag University Hospitals.
  • Confirmation of diagnosis histopathologically.
  • Availability of sufficient clinical, radiological, operative, and pathological data for analysis.

Exclusion criteria

  • Patients diagnosed with other types of thyroid malignancy (e.g., follicular, medullary, or anaplastic carcinoma).
  • Patients with a history of previous thyroid surgery before presentation to the study setting.
  • Patients with incomplete essential medical records that prevent confirmation of diagnosis or extraction of main study variables.

Treatment and study plan

Primary outcomes

  1. Prevalence of Extrathyroidal Extension in Papillary Thyroid Carcinoma

    Time frame: 9 months

    Percentage of participants with histologically confirmed extrathyroidal extension.

Secondary outcomes

  1. Incidence of Early Postoperative Surgical Complications

    Time frame: 9 months

    Percentage of participants experiencing early postoperative complications including hypocalcemia, recurrent laryngeal nerve palsy, hematoma, seroma, or wound sepsis.

  2. Incidence of Multifocal Papillary Thyroid Carcinoma

    Time frame: 9 months

    Percentage of participants found to have multifocal tumors on final histopathological examination.

  3. Rate of Cervical Lymph Node Metastasis

    Time frame: 9 months

    Percentage of participants with histopathologically confirmed cervical lymph node metastasis.

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Aboulabed Resident Ahmed Aboulabed Ahmed Mousa, resident

CONTACT

[email protected]

01114522110

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Pattern and Surgical Outcome of Papillary Thyroid Cancer: A Case Series Study at Sohag University Hospitals

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 16, 2026
Registry last updated
Sep 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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