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NCT Number: NCT07823192

A Randomized Controlled Trial Evaluating the Efficacy of Soaking Endotracheal Tube in Dexamethasone Solution for Prevention of Postoperative Sore Throat After Laparoscopic Cholecystectomy

The goal of this clinical trial is to learn if topical application of dexamethasone will prevent sore throat caused by endotracheal intubation in healthy patients undergoing elective surgery. The main question it aims to answer is:

• Does soaking the endotracheal tube in steroid solution before intubation lower the incidence of postoperative sore throat? Researcher will compare dexamethasone-soaked endotracheal tube to placebo (normal saline-soaked endotracheal tube) to see if topical steroid application in this way reduces development of sore throat.

Participants will be:

* Intubated with an endotracheal tube, that was either soaked in normal saline or dexamethasone solution, at induction of general anesthesia prior to undergoing elective cholecystectomy * Interviewed by the researcher 24 hours after their surgery to assess if they experienced any throat soreness

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Key information

Conditions

Post Operative Sore Throat

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

KRL Hospital Islamabad

Islamabad, 44000, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing general anesthesia requiring ETT insertion during elective laparoscopic cholecystectomy.
  • ASA I & ASA II patients
  • Patients consenting to be a part of the study

Exclusion criteria

  • Patients having diabetes mellitus
  • Patients with suspected or incidental difficult Intubation

Treatment and study plan

Steroid Drug

Drug

Endotracheal tube will be soaked in dexamethasone solution for 10 minutes prior to intubation

Normal (0.9%) saline

Drug

Endotracheal tube will be soaked in normal saline for 10 minutes prior to intubation

Primary outcomes

  1. Incidence of post operative sore throat

    Time frame: Within 24 hours of surgery

    Proportion of patients who develop sore throat after surgery

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Sponsors and collaborators

Lead sponsor

KRL Hospital, Islamabad

Other

Registry information

Official study title

Topical Dexamethasone Tube Soaking for Prevention of Postoperative Sore Throat (POST) Following Endotracheal Intubation for Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 16, 2026
Registry last updated
Sep 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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