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NCT Number: NCT07822581

"Discovery2" Study of Using MCG at Emergency Departments

The purpose of this research is to collect the magnetic signals from the heart to identify features that may help Emergency Department (ED) doctors differentiate high and low risk patients for heart related chest pain.

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Key information

Age range

22 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UCSF - Zuckerberg San Francisco General Hospital and Trauma Center

San Francisco, California, 94143, United States

Location contact

Katherine Steineman

CONTACT

[email protected]

707-718-3130

Lucas Zier, MD, MS

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women and men aged 22 years and older
  • Participant presenting with signs and symptoms suggestive of NSTE-ACS
  • In ED chest pain/NSTE-ACS care pathway
  • HEART Score 4+
  • Have received their first troponin result and can accommodate an MCG scan before the second troponin result.

Exclusion criteria

  • Unable to provide informed consent
  • ST elevation myocardial infarction (STEMI)
  • Active arrhythmia (as seen on the most recent ECG) such as atrial fibrillation, atrial flutter, ventricular tachycardia
  • Acute hemodynamic instability
  • Inability to lie supine and still for 5-10 minutes
  • Known or suspected pregnancy
  • Unable or unwilling to comply with required follow-up
  • Metallic passive implants that would make the participant unsuitable for MCG (e.g. spinal implants, metal shoulder replacements, dental implants.. etc.)
  • Active implantable medical devices (e.g. pacemakers, neurostimulators.. etc.)
  • Active illegal drug use per history of present illness
  • Contraindicated for temporary removal of telemetry during MCG scan
  • Clear non-ischemic cause for symptoms (e.g. trauma, viral infection, valve disease)
  • Clinical conditions that in the opinion of the Investigator would compromise the safety of the participant or ability to complete the protocol (e.g., exceeds bed weight limit, allergy to adhesives)

Treatment and study plan

Magnetocardiography

Device

The SandboxAQ CardiAQ System is an investigational device, and it is intended to non-invasively measure and display the magnetic signals produced by the electric currents in the heart. Its purpose is to assist in the evaluation of myocardial ischemia and infarction risks, in patients with symptoms suggestive of ACS. It is intended to complement clinical judgment and to augment standard of care diagnostic tools.

Primary outcomes

  1. Training machine learning algorithms.

    Time frame: Up to 30 Days

    The main objective of the study is to collect MCG and other clinical data from the intended patient population for training machine learning algorithms to identify the presence of High Risk - Coronary Artery Disease (HRCAD).

Secondary outcomes

  1. Changes in MCG over time

    Time frame: Day 1

    The second objective is to characterize changes in MCG, if any, over the course of a patient's evaluation workflow in the ED, with a repeat MCG scan.

Study contacts

Contact information is provided by the study sponsor or research team.

Maggie LeDang

CONTACT

[email protected]

408-981-8754

Sponsors and collaborators

Lead sponsor

SB Technology, Inc.

Industry

Registry information

Official study title

"Discovery2" Study of Using Magnetocardiography (MCG) at Emergency Departments

Acronym: Discovery2

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 16, 2026
Registry last updated
Sep 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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