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NCT Number: NCT07821710

Efficacy of Infection-site-targeted Postural Drainage in Mechanically Ventilated ICU Patients With Pulmonary Infection

This single-center, 1:1 randomized controlled trial aimed to evaluate the efficacy of infection-site-targeted postural drainage combined with mechanical vibration for mechanically ventilated ICU patients with pulmonary infection.

Eligible subjects were randomly assigned to either the personalized-care group (PCG, intervention) or routine-care group (RCG, control).

Patients in PCG received imaging-guided infection-site-targeted postural drainage plus mechanical vibration. Patients in RCG received standard routine position changes and mechanical vibration without imaging-guided targeted positional adjustment.

The primary outcome was duration of invasive mechanical ventilation. Secondary outcomes included PaO₂/FiO₂ ratio, ICU length of stay, total hospital length of stay, and 28-day all-cause mortality.

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Key information

Conditions

Pulmonary Infection Mechanical Ventilation Respiration Disorders Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wuxi Taihu Hospital

Wuxi, Jiangsu, 214003, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-80 years old;
  • Admitted to ICU and receiving invasive mechanical ventilation;
  • Clinically confirmed pulmonary infection;
  • Enrolled between May 2022 and October 2024.

Exclusion criteria

  • Unstable systemic disease contraindicating postural changes;
  • Active bleeding (gastrointestinal, intracranial, or pulmonary);
  • Requirement for continuous renal replacement therapy;
  • Raised intracranial pressure;
  • Neuromuscular disorder;
  • Multiple fractures or major trauma;
  • Severe hemodynamic instability;
  • Significant arrhythmias;
  • Severe delirium or altered mental status;
  • Pregnancy or lactation;
  • Currently participating in another interventional clinical trial.

Treatment and study plan

Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy.

Procedure

Imaging-guided infection-site-targeted postural drainage combined with mechanical vibration chest physiotherapy. The body position is individually adjusted according to pulmonary infection location shown on imaging examinations to facilitate sputum drainage.

Routine position change combined with mechanical vibration

Procedure

Routine regular position change combined with mechanical vibration chest physiotherapy. No imaging-guided targeted positional adjustment is performed; body position is changed following standard ICU nursing protocol only.

Primary outcomes

  1. Duration of mechanical ventilation

    Time frame: From initiation of invasive mechanical ventilation until successful extubation or death, assessed up to day 28.

Secondary outcomes

  1. 28-day mortality

    Time frame: All-cause mortality assessed at 28 calendar days from the date of randomization

  2. PaO₂/FiO₂ ratio

    Time frame: Measured at baseline (X1), Day 1, Day 2, Day 3, Day 4 post-randomization (X2-X4), and at weaning preparation (X5), all within 28 calendar days from randomization

  3. ICU length of stay

    Time frame: From randomization until ICU discharge, assessed up to 28 calendar days from randomization

  4. Total hospital length of stay

    Time frame: From randomization until hospital discharge, assessed up to 28 calendar days from randomization

Sponsors and collaborators

Lead sponsor

Affiliated Hospital of Jiangnan University

Other

Collaborators

  • Wuxi Taihu Hospital

Registry information

Official study title

A Randomized Controlled Trial of Infection-site-targeted Postural Drainage Combined With Mechanical Vibration for Mechanically Ventilated ICU Patients With Pulmonary Infection

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Sep 16, 2026
Registry last updated
Sep 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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