Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring

Inclusion criteria

• Adults aged 18 years or older.
• Diagnosis of drug-resistant epilepsy.
• Scheduled to undergo clinically indicated inpatient standard-of-care stereoelectroencephalography (SEEG) monitoring.
• Able and willing to provide written informed consent.
• In the investigator's judgment, able to comply with study procedures.

Exclusion criteria

• Any medical, neurological, psychiatric, or social condition that, in the investigator's judgment, would make participation unsafe or interfere with study procedures or data interpretation.
• Active infection, skin condition, or other finding at the planned subgaleal electrode placement site that could increase procedural risk.
• Known bleeding disorder, clinically significant coagulopathy, or use of anticoagulant/antiplatelet therapy that cannot be managed per institutional requirements for the planned procedure.
• Pregnancy or breastfeeding.
• Participation in another investigational study that, in the investigator's judgment, could interfere with TRACE procedures or outcomes.