Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis

Inclusion criteria

• Age ≥18 years at enrollment.
• Participant is willing and able to provide written informed consent.
• Able (in the Investigator's opinion) and willing to comply with all study requirements.
• Participant has or is suspected to have one of the following pulmonary conditions:
• Healthy volunteers: aged 18-30 years; no known cardiopulmonary disease; has not smoked tobacco products in the previous 5 years; smoking history, if any, is less than or equal to 5 pack-years; no history of using other inhaled products more than 1 time per week for > 1 year OR
• ILD-PH: ≥18 years; ILD diagnosis; precapillary PH by RHC (mPAP >20 mmHg, PVR >2 WU, PCWP ≤15 mmHg) within the specified window OR
• SSc: systemic sclerosis diagnosis with or without PH

Exclusion criteria

• Any condition which, in the opinion of the Investigator, would make it unsafe or unsuitable for the participants to undergo MRI (for example: presence of an implanted or external MRI unsafe device that cannot be removed, body weight exceeding table limitations, inability to lie flat, or severe claustrophobia).
• Inability to hold breath for 10-15 seconds for required imaging or for completion of DLCO measurements.
• Active pulmonary infection or lung cancer.
• Recent respiratory infection or pulmonary disease exacerbation within 4 weeks of screening.
• Participants who are known to be pregnant or lactating.
• Concurrent enrollment and participation in a study which, in the opinion of the Investigator, would interfere with the study compliance, or outcome assessments or would prohibit the collection of the required data points.