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NCT Number: NCT07820969

Post-op Analgesia of Nail Unit Procedures

The purpose of this study is to directly compare the efficacy of suzetrigine vs. oxycodone+acetaminophen vs. alternating acetaminophen/ibuprofen in controlling post-operative pain after the following nail unit procedures.

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Key information

Conditions

Nail Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Miami, Phillip Frost Dermatology Clinic

Miami, Florida, 33136, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients age 18+ able to understand and provide written consent in English or Spanish who present to Dr. Brian Morrison's clinic at the University of Miami and are undergoing a nail unit procedure.

Exclusion criteria

  • Patients under the age of 18 or adults unable to consent.
  • Patients who are pregnant or incarcerated.

Treatment and study plan

Suzetrigine

Drug

Participants will receive two 50 mg oral tablets on day 1, followed by 50 mg oral tablets every 12 hours for 5 days

Oxycodone + Acetaminophen

Drug

Participants will receive Oxycodone + acetaminophen combination administered orally at a dose of 50 mg/325 mg per tablet, every 6 hours for 5 days starting the day of the nail procedure

Acetaminophen/Ibuprofen

Drug

Participants will receive Acetaminophen administered orally at a dose of 650 mg every 6 hours for 5 days starting the day of the nail procedure. Alternate with ibuprofen 400 mg every 6 hours for 5 days starting day of nail procedure

Primary outcomes

  1. Change in Post-Operative Pain Intensity

    Time frame: 24 hours post nail procedure, 48 hours post nail procedure, 72 hours post nail procedure

    Pot-operative pain intensity measured using the Numeric Rating Scale (NRS, 0-10), where 0 indicates no pain and 10 indicates worst possible pain; higher scores indicate greater pain following nail unit procedures.

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Sponsors and collaborators

Lead sponsor

University of Miami

Other

Registry information

Official study title

Post-operative Analgesia of Nail Unit Procedures: A Prospective Pilot Study Comparing Suzetrigine vs. Oxycodone+Acetaminophen vs. Acetaminophen/Ibuprofen

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Sep 15, 2026
Registry last updated
Sep 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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