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NCT Number: NCT07820436

Interactive Robot-Guided Exercise Program for Cancer-Related Fatigue

The goal of this study is to learn whether an exercise program guided by an interactive robot can help reduce tiredness in people with cancer. This kind of tiredness, called cancer-related fatigue, is common during cancer treatment and can make everyday activities harder.

People who take part in the exercise program will do sessions guided by the robot. Before and after each session, the study team checks things like heart rate, breathing rate, and blood pressure, and asks about tiredness and other symptoms.

Family members and nurses who help patients use the robot are also asked to share their views on how well the robot's teaching materials hold their attention and help them feel confident and satisfied.

Everyone who joins the exercise part of the study receives the same robot-guided program. There is no separate group that skips the robot program.

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Key information

Conditions

Cancer Related Fatigue

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wanfang Hospital

Taipei, Taiwan

About this study

Cancer-related fatigue is one of the most common and distressing symptoms experienced by patients undergoing cancer treatment, often persisting despite rest and negatively affecting daily function and quality of life. Exercise is a recommended non-pharmacological strategy to help manage this symptom, but adherence to conventional exercise programs among cancer patients is often limited.

This study develops and evaluates an exercise teaching program delivered through an interactive robot (Kebbi) for cancer patients treated at Taipei Medical University-affiliated Wanfang Hospital. The robot guides participants through a structured exercise routine. Physiological parameters (heart rate, respiratory rate, systolic and diastolic blood pressure) are recorded immediately before and after exercise sessions, and patient-reported fatigue and symptom burden are assessed repeatedly over the course of the intervention period.

In addition to the patient cohort, family caregivers and nursing staff who interact with the robot-based teaching materials are invited to evaluate the instructional design of the materials, focusing on their ability to engage attention, demonstrate relevance, build confidence, and achieve satisfaction.

This is a single-group study; all enrolled patients receive the robot-guided exercise program, and outcomes are compared within participants before versus after the intervention. No randomization or control group is used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 20 years or older
  • Confirmed diagnosis of cancer, currently receiving anticancer treatment at Taipei Municipal Wanfang Hospital
  • Presence of cancer-related fatigue (self-reported or clinically assessed)
  • Sufficient cognitive and physical function to participate in a robot-guided, low-to-moderate intensity exercise program
  • Willing and able to provide informed consent

Exclusion criteria

  • Severe cognitive impairment or communication barriers preventing comprehension of study instructions
  • Unstable cardiopulmonary or hemodynamic status contraindicating exercise
  • Bedridden or physical performance status precluding participation in basic exercise movements

Treatment and study plan

Interactive Robot (Kebbi)-Guided Exercise Program

Behavioral

A structured exercise program delivered and guided by an interactive robot (Kebbi), designed to help manage cancer-related fatigue.

Primary outcomes

  1. Change in Cancer-Related Fatigue Severity

    Time frame: Baseline (prior to intervention) through completion of the intervention (up to 5 days), assessed up to three times daily during the intervention period

    Fatigue severity assessed using the Brief Fatigue Inventory (BFI), a self-reported measure with items rated from 0 (no fatigue) to 10 (fatigue as bad as you can imagine). Higher scores indicate greater fatigue severity.

Secondary outcomes

  1. Change in Symptom Burden

    Time frame: Baseline (prior to intervention) and immediately after completion of the intervention (up to 5 days)

    Symptom burden assessed using the Edmonton Symptom Assessment Scale (ESAS), which rates the severity of multiple symptoms (e.g., pain, tiredness, drowsiness, nausea, appetite) on a 0-10 scale. Higher scores indicate greater symptom severity.

  2. Change in Heart Rate

    Time frame: Immediately before and immediately after each exercise session, up to 4 sessions within the 5-day intervention period

    Heart rate (beats per minute) measured immediately before and immediately after each exercise session.

  3. Change in Respiratory Rate

    Time frame: Immediately before and immediately after each exercise session, up to 4 sessions within the 5-day intervention period

    Respiratory rate (breaths per minute) measured immediately before and immediately after each exercise session.

  4. Change in Systolic Blood Pressure

    Time frame: Immediately before and immediately after each exercise session, up to 4 sessions within the 5-day intervention period

    Systolic blood pressure (mmHg) measured immediately before and immediately after each exercise session.

  5. Change in Diastolic Blood Pressure

    Time frame: Immediately before and immediately after each exercise session, up to 4 sessions within the 5-day intervention period

    Diastolic blood pressure (mmHg) measured immediately before and immediately after each exercise session.

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Taipei Medical University

Other

Registry information

Official study title

Using an Interactive Kebbi Robot to Develop an Exercise Program for Cancer-Related Fatigue: Assessing Its Effectiveness

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 15, 2026
Registry last updated
Sep 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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