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NCT Number: NCT07819526

Acute Ischemic Stroke in Patients With Active Cancer

The goal of this multicenter prospective observational study, conducted at 24 hospitals in Japan, is to learn about recurrent ischemic stroke in people with active cancer who develop acute ischemic stroke. One of the main objectives is to evaluate how often ischemic stroke recurs during follow-up.

The main questions this study aims to answer are:

* How often does ischemic stroke recur within 3 months after the initial stroke? * Which clinical factors may be associated with recurrent ischemic stroke? * What other clinical outcomes occur during follow-up?

Participants will receive medical care determined by their treating physicians. Researchers will collect information about participants' cancer, stroke characteristics, test results, treatments, recurrent ischemic stroke, and other clinical outcomes. Researchers will also explore whether clinical factors are associated with recurrent ischemic stroke and other outcomes. This study will not assign participants to a specific treatment.

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Key information

Conditions

Acute Ischemic Stroke Active Cancer Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Neoplasms Nervous System Diseases Stroke Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

The Univeristy of Osaka

Suita, Osaka, 565-0871, Japan

Location status: Recruiting

Location contact

Yasufumi Gon, MD, PhD

CONTACT

[email protected]

+81-6-6879-5111

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute ischemic stroke diagnosed within 7 days after symptom onset or the time last known well.
  • Active cancer at the time of the index stroke, as defined below.

Exclusion criteria

  • The patient or a legally acceptable representative indicates that the patient does not wish to participate.
  • The investigator considers enrolment inappropriate.

Treatment and study plan

Primary outcomes

  1. Percentage of Participants With Recurrent Ischemic Stroke Within 3 Months

    Time frame: From enrollment through 3 months of follow-up

    The percentage of participants who experience recurrent ischemic stroke during follow-up. Recurrent ischemic stroke will be determined according to the criteria prespecified in the study protocol.

Sponsors and collaborators

Lead sponsor

Osaka University

Other

Registry information

Official study title

Clinical Characteristics and Stroke Recurrence in Patients With Acute Ischemic Stroke and Active Cancer: The CAT-AIS Multicenter Prospective Observational Study

Acronym: CAT-AIS

Important dates

Study start
2026
Primary completion
2027
Study completion
2032
First posted
Sep 15, 2026
Registry last updated
Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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