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NCT Number: NCT07819448

Aerobic Exercise as an Adjunct Therapy for Depression

The goal of this study is to compare the reduction in the severity of depression after a duration of 06 weeks between patients receiving conventional therapy (antidepressant; Sertraline) only and those receiving both conventional therapy and a structured aerobic exercise (cycling, brisk walking).

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Key information

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CMH Bahawalpur

Chak Four Hundred Fifty-four, Punjab Province, 63100, Pakistan

Location status: Recruiting

Location contact

Beenish Hassan Khan, MBBS, FCPS Psychiatry

PRINCIPAL_INVESTIGATOR

Manahil Gill, MBBS

CONTACT

[email protected]

+92 304 6527981

Manahil Gill, MBBS, Registrar Psychiatry

PRINCIPAL_INVESTIGATOR

Mansoor Mustafa, MBBS, FCPS Psychiatry

PRINCIPAL_INVESTIGATOR

About this study

This study will compare two groups A and B for 06 weeks to study the reduction in severity of depression.

  • Comparison group (Group-A): In this group participants will receive standard antidepressant treatment such as Sertraline (SSRIs) and psychotherapy (CBT) only. After 06 weeks, patients will again be assessed for their level of depression using the BDI scale.
  • Experimental group (Group-B): In this group participants will undergo structured exercise program in addition to conventional pharmacotherapy and psychotherapy. They will be introduced to aerobic exercises which includes cycling and brisk walking and will undergo three supervised sessions for 35 minutes each, per week for total 06 weeks under supervision of trainee psychiatry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

i. All new patients diagnosed with moderate and severe depression using BDI scale according to ICD-11 criteria between the ages of 18-55 years.

ii. Both genders will be included.

Exclusion criteria

i. Patients with severe physical disabilities such as Spinal cord injuries, severe osteoporosis or medical conditions that prevent exercise such as ischemic changes in ECG pre-exercise.

ii. Pregnant females. iii. Individuals already engaging in physical activities like athletes.

Treatment and study plan

Structured Aerobic exercise

Behavioral

Participants will receive structured, supervised aerobic exercise ( cycling, brisk walking), in addition to conventional treatment consisting of 03 sessions per week, 35 minutes each for 06 weeks.

Primary outcomes

  1. Change in Beck Depression Inventory (BDI) score

    Time frame: Baseline to 06 weeks

    The primary outcome will be the mean change in Beck Depression Inventory (BDI) score from baseline to the end of 06 weeks intervention period. It is a 21- item self-report scale with total scores ranging from 0 to 63. Lower scores indicate fewer depressive symptoms and therefore a better outcome. The mean change in BDI score will be compared between the aerobic exercise (plus conventional treatment ) group and the non exercise group. (conventional treatment only).

Study contacts

Contact information is provided by the study sponsor or research team.

Manahil Gill, MBBS

CONTACT

[email protected]

+92 304 6527981

Muhammad Ahsan Mustafa, MBBS

CONTACT

+ 92 333 3396180

Sponsors and collaborators

Lead sponsor

Manahil Gill

Other

Registry information

Official study title

Role of Aerobic Exercise as an Adjunct Therapy in the Treatment of Depression in South Punjab, Pakistan

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 15, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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