Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.

The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.

Completed

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Key information

Conditions

White Spot Lesion of Tooth

Age range

13 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ALAzaher

Cairo, Egypt

About this study

A single-blinded, parallel-group, randomized clinical trial design was followed. 90 teeth with white spot lesions (WSLs) were selected from 30 patients. The participants were randomly assigned into six groups (n=15/group) according to the applied treatment agent (Remin Pro, X Pur Remin, and Pro-fluoride varnish) with diode laser (an average power of 1W, Exposure time of 10 s, diode 810 nm, speed of 1 mm/sec), and Elexxion Perio Green dye or without diode laser

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The patients should be 13e40 years old. The patients should have good oral hygiene, general health, and no systemic disease.

Exclusion criteria

presence of enamel hypoplasia, dental fluorosis, and carious cavity. These patients have diminished salivary flow or significant tooth wear, and concurrent participation in other clinical trials

Treatment and study plan

remin pro

Drug

effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic technique

Other names: xpur remin

Primary outcomes

surface area measurement white spot lesion (image anylsis)

Time frame: one month

The I sensor was a USP-driven digital sensor intended to acquire dental intraoral radiograph images. It was combined with the customized poisoning device supplied with the system. One month after the finalization of the remineralization protocol, another radiographic examination was undertaken. Before subtraction, gamma correction was applied to standardize the density and contrast, and images were obtained and saved as Tagged Image File Format (TIFF) and jpg. used image software for each area (Image J software), and follow-up images were subtracted from the base

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Effect of Diode Laser and Dye With Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques. Randomized Clinical Trial

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2023
First posted: Sep 14, 2026
Registry last updated: Sep 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed