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OpenTrials
Completed

NCT Number: NCT07818408

Value of Optic Nerve Sheath Diameter in Differentiating Ischemic From Hemorrhagic Stroke

We aimed to examine bedside ONSD values measured by ocular ultrasonography in patients presenting to the ED with stroke, and to determine a diagnostic cut-off value for differentiating ischemic from hemorrhagic stroke.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Bilkent City Hospital Emergency Medicine Department

Ankara, Turkey (Türkiye)

About this study

This study was conducted prospectively and observationally in the adult emergency department of a tertiary training and research hospital. Patients older than 18 years who presented to the ED with stroke on the investigator's shift days, who were not followed up or treated by the investigator, and who were diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI) were included in the study. Patients who were intubated, those who were unwilling to participate, and those in whom mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, optic neuritis, or any cause that could lead to cerebral edema or affect the ONSD by raising ICP was identified in their history or on imaging were excluded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients older than 18 years presenting to the ED with stroke.
  • Patients diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI).

Exclusion criteria

  • Patients who are intubated. Patients unwilling to participate.
  • History or imaging findings of mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, or optic neuritis.
  • Any condition leading to cerebral edema or affecting ONSD by independently raising intracranial pressure.

Treatment and study plan

Bedside Ocular Ultrasonography (ONSD Measurement)

Diagnostic Test

Measurement of the optic nerve sheath diameter using a high-frequency (4-10 MHz) linear probe at 3 mm posterior to the papilla, immediately after the CT/MRI procedure.

Primary outcomes

  1. Cut-off Value of Optic Nerve Sheath Diameter (ONSD)

    Time frame: Evaluated immediately following the initial imaging procedure (CT/MRI) in the emergency department.

    Determination of the optimal ONSD cut-off value (in millimeters) to effectively differentiate between ischemic and hemorrhagic stroke subtypes.

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Official study title

Diagnostic Value of Bedside Ultrasonographic Optic Nerve Sheath Diameter Measurement in Differentiating Ischemic From Hemorrhagic Stroke in the Emergency Department

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Sep 14, 2026
Registry last updated
Sep 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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