Peroxide Versus Non-Peroxide In-Office Tooth Bleaching: A Randomized Clinical Trial

This randomized controlled clinical trial is designed to compare the clinical performance of peroxide-based and non-peroxide in-office tooth bleaching systems. Eligible participants will be randomly allocated into two treatment groups. Tooth color will be assessed using standardized clinical evaluation methods before treatment, immediately after bleaching, and during follow-up visits. The study will also evaluate color stability and tooth sensitivity over a six-month follow-up period. The findings are expected to provide evidence regarding the effectiveness and safety of both bleaching systems and to support evidence-based clinical decision-making in esthetic dentistry.

Inclusion criteria

• Adults aged 18-45 years.
• Good general health.
• Presence of all maxillary anterior teeth free from restorations, caries, or structural defects.
• Baseline tooth shade suitable for bleaching assessment.
• Good oral hygiene and periodontal health.
• Willingness to comply with the study protocol and attend all follow-up visits.
• Signed informed consent.

Exclusion criteria

• Pregnancy or lactation.
• History of tooth hypersensitivity.
• Active caries or defective restorations in the anterior teeth.
• Intrinsic tooth discoloration (e.g., fluorosis, tetracycline staining).
• Ongoing orthodontic treatment.
• Smoking.
• Use of tooth-whitening products within the previous 6 months.
• Allergy to any component of the bleaching materials.