Phage-based Control and Limitation of Pathobionts for Microbiome Equilibrium and Resilience

Inclusion criteria

• Between 18-75 years old
• BMI <30
• Experiencing mild-moderate gastrointestinal distress/ abdominal pain, bloating, constipation, and/or diarrhea

Exclusion criteria

• Younger than 18 years old or greater than 75 years old
• BMI >29.9
• Antibiotic use in the past 2 months
• Use of statins, metformin, prescription NSAIDs, and MAO inhibitors, or other medications that could interfere with study outcomes, as determined by the study PI
• Current diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, or cardiometabolic disease (diabetes, cardiovascular disease)
• Individuals with allergies to capsule ingredients
• Pregnant or breastfeeding individuals
• Excess alcohol consumption (≥4 drinks on any given occasion and/or ≥8 drinks/week for women, and ≥5 drinks on any given occasion and/or ≥15 drinks/week for men)
• Use of dietary supplements that contain probiotics or phages
• Actively trying to lose weight
• Participation in other research studies that would interfere with study endpoints or compliance
• Unable or unwilling to consume capsules, provide stool or blood samples, track bowel movements and symptoms, and attend scheduled clinic visits