Impact of Iron Supplementation During Pregnancy

During pregnancy, iron deficiency is the most common cause of anemia. Anemia is very common during pregnancy and after childbirth. Around half of pregnant women develop anemia, and after delivery, up to 85% of women may be affected.

This study looks at whether iron given through a vein (intravenous iron) can improve blood levels and how women feel and function in everyday life before and after giving birth.

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Key information

Conditions

Anemia Hematologic Diseases Hemic and Lymphatic Diseases Iron Deficiencies Iron Deficiency Anaemia in Childbirth Iron Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Pregnancy

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

University Hospital Frankfurt, Department for Anaesthesiolgy, Intensive Care, and Pain Therapy, Frankfurt, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pregnancy

Exclusion criteria

Thalassemia
Sickle cell disease
Aplastic anemia
Hemochromatosis
Chronic inflammatory diseases associated with anemia of chronic disease
Severe renal insufficiency
Intravenous iron administration within 3 months prior to enrollment

Treatment and study plan

Iron

Drug

Iron supplementation will be performed according to Hamza et al., Recommendations of the AGG (Obstetrics Working Group, Section for Maternal Diseases) for the Management of Anemia in Pregnancy - Part 1 (Iron Deficiency Anemia) (https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-2628-7308.pdf)

Primary outcomes

Proportion of patients achieving an increase in hemoglobin concentration of ≥1 g/dL

Time frame: between iron supplementation and follow-up: 2-4 weeks

Proportion of patients with an increase in hemoglobin concentration of ≥1 g/dL from before the first intravenous iron administration to the last available measurement before delivery

Study contacts

Contact information is provided by the study sponsor or research team.

Patrick Meybohm, MD

CONTACT

[email protected]

+49 931 201-30001

Suma Choorapoikayil, PhD

CONTACT

[email protected]

049-069-6301-83169

Sponsors and collaborators

Lead sponsor

Johann Wolfgang Goethe University Hospital

Other

Collaborators

Wuerzburg University Hospital

Registry information

Official study title

Impact of Iron Supplementation on Haemoglobin Levels and Quality-of-life in Iron-deficient (Anaemic) Women Before and After Delivery

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2028
First posted: Sep 11, 2026
Registry last updated: Sep 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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