Clinical Evaluation of Zirconium Dioxide Nano-Coated Arch Wires

"This clinical trial aims to evaluate the clinical performance and efficiency of zirconium dioxide nano-coated orthodontic archwires compared to conventional archwires. The study focuses on assessing the leveling and alignment duration, as well as evaluating patient comfort and clinical outcomes during the initial stages of orthodontic treatment."

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Key information

Conditions

Malocclusion of Anterior Teeth

Age range

13 year–19 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants within the age range of 13 to 19 years.
Moderate crowding (4-6 mm) in the maxillary anterior segment, evaluated using the Little Irregularity Index (LII), indicating the need for treatment with a fixed appliance without extractions.
Patients in permanent dentition with all teeth had fully erupted ( excluding 3rd molars)
Good oral hygiene.
No previous orthodontic treatment.

Exclusion criteria

Transverse and/or vertical skeletal dysplasia or craniofacial malformation
Retained primary or missing permanent teeth in the maxillary anterior area.
Present or history of periodontal diseases.
Physical or mental disability.
Systemic diseases or regular use of medications that could interfere with orthodontic tooth movement.

Treatment and study plan

Zirconium dioxide nano-coated archwire

Device

Zirconium dioxide nano-coated nickel-titanium archwire used during the leveling and alignment phase of fixed orthodontic treatment, compared against conventional uncoated NiTi archwires."

Conventional orthodontic archwire

Device

Conventional orthodontic archwire used during the leveling and alignment phase of fixed orthodontic treatment, compared against Zirconium dioxide nano-coated nickel-titanium archwire

Primary outcomes

Rate of dental alignment

Time frame: Measured at baseline and every 4 weeks up to 16 weeks .

Little's Irregularity Index (unabbreviated scale title). The index measures the linear displacement of the five anatomic points of the anterior teeth. Scores range from a minimum of 0 (representing perfect alignment with no displacement) to a maximum of 10 or higher (representing severe dental crowding and irregularity). Lower scores indicate a better outcome (greater dental alignment and successful leveling phase).

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed E Desoky, postgraduate student

CONTACT

[email protected]

+201020353336 ext. +20

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Assessment of the Role of Zirconium Dioxide Nanocoating of Arch Wires on the Rate of Orthodontic Tooth Movement During Leveling and Alignment: A Comparative Clinical Study

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2028
First posted: Sep 10, 2026
Registry last updated: Sep 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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