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NCT Number: NCT07812610

Mineralized Dentin Graft Versus Beta-Tricalcium Phosphate for Alveolar Ridge Preservation

The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed.

Participants were randomly assigned to one of three groups. One group received no bone graft material. One group received mineralized dentin graft made from the participant's extracted tooth. One group received beta-tricalcium phosphate, which is a synthetic bone graft material.

Participants had cone-beam computed tomography, a three-dimensional dental X-ray, immediately after tooth removal and again after 6 months. During dental implant placement at 6 months, researchers collected a small bone sample to examine healing.

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Key information

Conditions

Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Mansoura University

Al Mansurah, Aldakhlia, 35516, Egypt

About this study

After tooth extraction, the alveolar ridge undergoes natural remodeling that can reduce its width and affect future dental implant placement. Alveolar ridge preservation aims to limit these dimensional changes. This randomized controlled clinical trial compared autogenous mineralized dentin graft, beta-tricalcium phosphate, and healing without bone graft material following extraction of hopeless maxillary teeth.

Participants were randomly assigned in a 1:1:1 ratio to three groups. The control group received no bone graft material. The mineralized dentin graft group received graft particles prepared from the participant's extracted tooth. The beta-tricalcium phosphate group received a synthetic bone graft material.

Alveolar ridge width was measured using cone-beam computed tomography immediately after extraction and at 6 months.

During delayed dental implant placement at 6 months, a small bone-core sample was collected from each study site.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 years or older.
  • Clinical indication for extraction of a hopeless maxillary tooth.
  • No evidence of acute infection at the intended extraction site.
  • Willing and able to comply with the scheduled study visits and follow-up procedures.
  • Provided written informed consent.

Exclusion criteria

  • Systemic disorder known to impair bone metabolism.
  • History of radiotherapy involving the head and neck region.
  • Pregnancy or lactation.
  • Advanced periodontal disease.

Treatment and study plan

Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft

Procedure

Following atraumatic tooth extraction, an autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket.

Alveolar Ridge Preservation With Beta-Tricalcium Phosphate

Procedure

Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket.

Extraction Socket Healing Without Bone Graft

Procedure

Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket.

Primary outcomes

  1. Change in Alveolar Bone Width From Baseline to 6 Months

    Time frame: Baseline immediately after tooth extraction and 6 months

    Alveolar bone width was measured in millimeters using cone-beam computed tomography immediately after tooth extraction and at 6 months. Width was measured horizontally from the outer buccal cortical surface to the palatal cortical surface.

Sponsors and collaborators

Lead sponsor

Soaad Tolba Mohammed Tolba Badawi

Other

Registry information

Official study title

From Tooth to Bone: Can Mineralized Dentin Graft Be a Viable Alternative to Beta-Tricalcium Phosphate for Alveolar Ridge Preservation? A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 10, 2026
Registry last updated
Sep 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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