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NCT Number: NCT07812519

Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain

This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. The participants will throughout the exercise trial report pain levels and continue until 1) not being able to perform the exercise as instructed or 2) reaching a pain level of 5/10 (which is a common threshold for acceptable pain within rehabilitation). During this trial, the participants will be filmed and a biomechanical analysis will be performed to see if/how compensatory movements occur.

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Key information

Conditions

Patellofemoral Pain Syndrome Joint Diseases Musculoskeletal Diseases

Age range

15 year–35 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with PFP in only one knee by a licensed healthcare professional.
  • Aged 15-35 years.
  • A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.

Exclusion criteria

  • Any prior injury or condition with residual symptoms that may affect the results.
  • Current injury or condition affecting the performance of the test.
  • Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.

Treatment and study plan

EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Other

Resistance training to muscular failure in patients with patellofemoral pain.

Primary outcomes

  1. Pain Response

    Time frame: Approximately 24 hours, from baseline before the trial and the day after the trial.

    Numeric pain rating scale 0-10. Participants will rate their perceived pain at baseline before the trial, during the trial and the day after the trial.

  2. Knee extensor moment (Nm)

    Time frame: Changes in knee extensor moment between the first and final repetition during the trial, approximately 2 minutes.

    Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)

  3. Hip extensor moment (Nm)

    Time frame: Changes in hip extensor moment between the first and final repetition during the trial, approximately 2 minutes.

    Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)

  4. Knee flexion angle (degrees)

    Time frame: Changes between in knee flexion angle between the first and final repetition during the trial, approximately 2 minutes.

    Knee flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)

  5. Hip flexion angle (degress)

    Time frame: Changes between in hip flexion angle between the first and final repetition during the trial, approximately 2 minutes.

    Hip flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Ted Gunhamn

Other

Collaborators

  • Molndal Hospital
  • Västra Götalandsregionen

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Sep 10, 2026
Registry last updated
Sep 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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