Centre Hospitalier de Cayenne
Cayenne, French Guiana, 97300
Location contact
Cassio De Figueiredo Azze, MCs
PRINCIPAL_INVESTIGATOR
Cassio De Figueiredo Azze, MSc
CONTACT
Estelle Thomas, MPH
CONTACT
NCT Number: NCT07808801
In French Guiana, Indigenous people experience high levels of psychological distress and higher rates of suicidal behavior than the rest of the population.
The Wayãpi and Teko communities living in Camopi and Trois-Sauts are particularly affected.
Since 2025, Community Workers (CHWs) from these communities have been appointed to facilitate access to care, improve communication between residents and health services, and strengthen support in situations of distress.
To date, no scientific evaluation has been conducted to measure the actual impact of this initiative. This research therefore aims to better understand mental health in these communities and to assess the effect of the community mediators' work.
The results will help improve suicide prevention efforts and adapt public health policies to local realities.
The purpose of this study is to assess the impact of CHWs activities on:
* suicidal behavior, * psychological distress, * alcohol use, * use of health care services, within the Wayãpi and Teko communities of Camopi and Trois-Sauts.
Trial opening soon.
Get Notified12 year and older
All sexes
Observational
Cayenne, French Guiana, 97300
Cassio De Figueiredo Azze, MCs
PRINCIPAL_INVESTIGATOR
Cassio De Figueiredo Azze, MSc
CONTACT
Estelle Thomas, MPH
CONTACT
The mental health of Indigenous peoples is a major public health and social justice issue. Approximately 370 million Indigenous people live in more than 90 countries, sharing common experiences of historical exclusion, territorial dispossession, and socioeconomic marginalization. These structural determinants result in persistent health inequalities, including suicide rates that are frequently higher than national averages.
International data show significant variability-ranging from 0 to 187.5 suicides per 100,000 people -highlighting the importance of cultural and historical contexts. Ethnicity is not a risk factor in and of itself; vulnerabilities arise from the interaction between historical trauma, socioeconomic conditions, and local cultural dynamics.
The literature highlights three key factors:
International comparisons confirm that communities with territorial control, autonomous institutions, or adapted educational systems have significantly lower suicide rates.
The Amazon is a region particularly affected by inequalities in Indigenous mental health. Despite remarkable linguistic and cultural diversity, the region remains marked by the legacy of colonization, resource exploitation, missionary activity, and a chronic lack of health and educational infrastructure.
Available data indicate that suicide rates reach particularly high levels in several Amazonian contexts: up to twenty times the national average among the Guarani-Kaiowá in Brazil, 247.9 per 100,000 inhabitants among the Emberá Dobidá in Colombia, and rates higher than the national average in the Ecuadorian Amazon. These situations reflect the cumulative effect of structural, social, and historical vulnerabilities, the manifestation of which varies according to national and local contexts.
Although it is a department of a high-income country, French Guiana exhibits health inequalities comparable to those observed in low-resource settings. The Amazonian interior, accessible only by canoe or plane, suffers from significant geographic isolation, limiting access to specialized care.
In French Guiana, the municipality of Camopi, which includes the village of Trois-Sauts, has particularly high suicide rates, estimated at 113 and 137 per 100,000 inhabitants, respectively, with suicide attempt rates approaching 400 per 100,000 inhabitants. Suicides primarily affect young people aged 10 to 29, who account for more than 60% of suicide deaths, with an average age of 25 in the interior compared to 36 on the coast.
The observed vulnerabilities result from a complex interplay of factors: alcohol abuse and substance use disorders, domestic violence, a loss of identity due to rapid sociocultural changes, as well as the social and environmental impacts of illegal gold mining. These factors interact within a context of severe social precariousness and the erosion of community structures.
The concentration of psychiatric services in the prefecture and main French Guina town, Cayenne, the language barrier (with Wayãpi and Teko being the predominant languages), and the lack of interventions that are sustainably adapted to Indigenous contexts hinder the effectiveness of existing systems, exacerbating inequalities in access to and care for mental health.
Beyond socioeconomic and health determinants, the situations of psychological distress observed in Wayãpi and Teko communities are embedded in culturally situated frameworks of understanding. Representations of psychological distress, illness, and suicide are inseparable from a relational worldview in which bodily, social, territorial, and symbolic dimensions are closely intertwined.
In this context, psychological distress is not viewed exclusively as an individual disorder, but as an imbalance affecting the relationships between the individual, their social environment, and the symbolic frameworks mobilized to make sense of their lived experience. The failure to take these interpretive frameworks into account in healthcare systems constitutes an additional factor contributing to underutilization of services and the ineffectiveness of interventions.
In many countries, community health workers (CHWs) are a key lever for reducing health inequalities. Their cultural proximity facilitates early detection of health issues, language mediation, psychosocial support, and adherence to care.
In French Guiana, six Wayãpi and Teko Community Health Workers (CHWs) were deployed in 2025 in the municipalities of Camopi and Trois-Sauts. They serve as a bridge between so-called "traditional" medicine and allopathic medicine, facilitating access to care and the management of distressing situations.
Despite these advances, several gaps remain:
These gaps hinder the development of appropriate prevention policies and keep the communities' real needs hidden. Three key findings emerge:
This is a single-center, quasi-experimental, prospective before-and-after study conducted in the municipality of Camopi (including Trois-Sauts).
The secondary objectives aim to document the mechanisms, cultural dimensions, and social effects associated with the CHWs' intervention:
The expected benefits apply to communities, health institutions, and scientific knowledge alike.
For the Wayãpi and Teko communities:
For institutional stakeholders:
For research:
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: From inclusion to 12, 24 and 30 months after CHWs intervention
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the study population, comparing retrospective suicidal behaviour rates in the 5 years before with propective suicidal behaviour rates at 12, 24 and 30 months after the intervention of CHWs among the study population
Time frame: From inclusion to 12, 24 and 30 months
Measurement of psychological distress score using the validated K10 scale
Time frame: From inclusion to 12, 24 and 30 months
Measurement of alcohol use pattern using the validated AUDIT-C scale
Time frame: From inclusion to 12, 24 and 30 months
Number of out patient visits and hospitalisations in psychiatric and general medical services
Time frame: From inclusion to 12, 24 and 30 months
Analysis of the cultural representations of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants
Time frame: From inclusion to 12, 24 and 30 months
Analysis of the community perceptions of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants
Time frame: From inclusion to 12, 24 and 30 months
Measurement of the community solidarity and perception of community stigma using individual qualitative questionnaires and focus group strategies
Time frame: At 12, 24 and 30 months
Measurement of the level of management and support needed by CHWs in their activities using qualitative questionnaires
Contact information is provided by the study sponsor or research team.
Centre Hospitalier de Cayenne
Other
Acronym: MCS Impact
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