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NCT Number: NCT07808658

Effect of Box Breathing Before Chest Tube Removal After Open-Heart Surgery

This randomized controlled trial aims to evaluate the effects of box breathing performed before chest tube removal on pain, anxiety, dyspnea, and hemodynamic parameters in patients undergoing open-heart surgery. A total of 86 patients will be randomly assigned in a 1:1 ratio to either the box breathing group or the control group. Participants in the intervention group will perform the 4-4-4-4 box breathing technique for approximately five minutes before chest tube removal in addition to routine care, while participants in the control group will receive routine care only. Pain, anxiety, dyspnea, and hemodynamic parameters will be assessed before and at specified time points after chest tube removal.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Turkey, Mersin University Hospital

Yenişehir, Mersin, 33120, Turkey (Türkiye)

Location contact

Tuğba ÇAM YANIK, PhD

CONTACT

[email protected]

05067703216

About this study

Chest tube removal is a routine procedure following open-heart surgery; however, it may cause pain, anxiety, dyspnea, and changes in hemodynamic parameters. Nonpharmacological interventions that are simple, safe, and easy to apply may contribute to symptom management during this procedure.

This prospective, two-arm, parallel-group randomized controlled trial will evaluate the effects of box breathing performed before chest tube removal in patients undergoing open-heart surgery. A total of 86 eligible patients will be randomly assigned in a 1:1 ratio to the intervention group (n=43) or control group (n=43) using block randomization.

Participants assigned to the intervention group will receive routine care and perform the box breathing technique approximately five minutes before chest tube removal. The technique consists of four phases of equal duration: inhaling for 4 seconds, holding the breath for 4 seconds, exhaling for 4 seconds, and holding after exhalation for 4 seconds. Participants will perform 15 consecutive cycles for approximately five minutes under the verbal guidance of the researcher. The exercise will be completed immediately before chest tube removal. Participants in the control group will receive routine clinical care without an additional nonpharmacological intervention.

Pain intensity will be assessed using the Visual Analog Scale (VAS), anxiety using the Visual Analog Scale for Anxiety (VAS-A), and dyspnea using the Visual Analog Scale for Dyspnea (VAS-D). Hemodynamic parameters will include systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, and peripheral oxygen saturation (SpO2).

Assessments will be performed at five time points: before the box breathing intervention (T0), immediately after chest tube removal (T1), and at 5 minutes (T2), 15 minutes (T3), and 30 minutes (T4) after chest tube removal. Both groups will continue to receive routine medical treatment and nursing care throughout the study.

The primary outcome is pain intensity associated with chest tube removal. Secondary outcomes are anxiety, dyspnea, systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, and peripheral oxygen saturation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who have undergone open-heart surgery and have a chest tube Aged 18 years or older Willing to participate in the study and providing written informed consent Conscious, oriented, and cooperative Able to read and understand Turkish Clinically and hemodynamically stable Having no more than three chest tubes (up to two mediastinal and one thoracic chest tube) No diagnosed psychiatric disorder Not receiving psychiatric medications and/or local neuromuscular blocking agents

Exclusion criteria

Patients who have not undergone open-heart surgery Unconscious, disoriented, or uncooperative patients Unable to read and understand Turkish Intubated patients Receiving additional analgesic medication other than routine analgesia Receiving local anesthesia at the chest tube insertion site Having four chest tubes (two mediastinal and two thoracic) Unwilling to participate in the study Having a diagnosed psychiatric disorder or mental health condition

Treatment and study plan

Box Breathing

Behavioral

Participants will perform the 4-4-4-4 box breathing technique approximately five minutes before chest tube removal. The technique consists of inhaling through the nose for 4 seconds, holding the breath for 4 seconds, exhaling for 4 seconds, and holding after exhalation for 4 seconds. Participants will perform 15 consecutive cycles for approximately five minutes under the verbal guidance of the researcher. The intervention will be completed immediately before chest tube removal. Routine medical treatment and nursing care will continue throughout the intervention.

Primary outcomes

  1. Pain Intensity

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst possible pain). Higher scores indicate greater pain intensity.

Secondary outcomes

  1. Anxiety Level

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Anxiety will be assessed using the 10-cm Visual Analog Scale for Anxiety (VAS-A), ranging from 0 (no anxiety) to 10 (highest possible anxiety). Higher scores indicate greater anxiety.

  2. Dyspnea Level

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Dyspnea will be assessed using the 10-cm Visual Analog Scale for Dyspnea (VAS-D), ranging from 0 (no dyspnea) to 10 (worst imaginable dyspnea). Higher scores indicate greater dyspnea.

  3. Systolic Blood Pressure

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Systolic blood pressure will be measured using a bedside patient monitor and recorded in millimeters of mercury (mmHg).

  4. Diastolic Blood Pressure

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Diastolic blood pressure will be measured using a bedside patient monitor and recorded in millimeters of mercury (mmHg).

  5. Heart Rate

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Heart rate will be measured using a bedside patient monitor and recorded as beats per minute (beats/min).

  6. Respiratory Rate

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Respiratory rate will be assessed by the researcher by observing and counting chest movements for one minute and will be recorded as breaths per minute.

  7. Peripheral Oxygen Saturation (SpO2)

    Time frame: Before the intervention, immediately after chest tube removal, and 5, 15, and 30 minutes after chest tube removal.

    Peripheral oxygen saturation (SpO2) will be measured using a bedside patient monitor and recorded as a percentage (%).

Study contacts

Contact information is provided by the study sponsor or research team.

TUGBA ÇAM YANIK, PHD, RN

CONTACT

[email protected]

05067703216

Tuğba ÇAM YANIK, PHD

CONTACT

[email protected]

05067703216

Sponsors and collaborators

Lead sponsor

Mersin University

Other

Registry information

Official study title

The Effect of Box Breathing Before Chest Tube Removal After Open-Heart Surgery on Pain, Anxiety, Dyspnea, and Hemodynamic Parameters: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 9, 2026
Registry last updated
Sep 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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