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Completed

NCT Number: NCT07807709

Evaluation of Jugular Venous Distensibility Index in Intravascular Fluid Management and Comparison of the Effectiveness of Noninvasive and Minimally Invasive Methods

Assessment of intravascular volume status is an important component of hemodynamic management in critically ill patients. Several noninvasive and minimally invasive parameters, including the pleth variability index (PVI), pulse pressure variation (PPV), stroke volume variation (SVV), and ultrasonographic measurements of venous diameter variation, can be used for this purpose. Although the inferior vena cava distensibility index (IVC-DI) is commonly evaluated using ultrasonography, visualization of the inferior vena cava may be technically difficult or time-consuming in some patients. The right internal jugular vein is more superficial and may therefore provide a faster and more accessible alternative.

The primary aim of this prospective observational study is to evaluate the correlation and agreement between the right internal jugular vein distensibility index (RJV-DI) and IVC-DI in mechanically ventilated adult intensive care unit patients. The secondary aims are to compare the correlations of RJV-DI and IVC-DI with PVI, PPV, and SVV and to compare the acquisition times of the two ultrasonographic measurements. The study will assess whether RJV-DI may provide a practical and faster alternative for hemodynamic assessment, particularly when visualization of the inferior vena cava is difficult.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Gaziosmanpasa Training Research Hospital

Istanbul, 34255, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Admission to the intensive care unit
  • Receiving invasive mechanical ventilation at the time of assessment
  • Availability of PVI, PPV, and SVV measurements during the hemodynamic assessment
  • Availability of technically adequate right internal jugular vein and inferior vena cava ultrasonographic measurements obtained during the same assessment session

Exclusion criteria

  • Age younger than 18 years
  • Presence of cardiac arrhythmia
  • Not receiving invasive mechanical ventilation at the time of assessment
  • Inability to obtain technically adequate right internal jugular vein or inferior vena cava ultrasonographic images
  • Unavailable or incomplete PVI, PPV, or SVV measurements

Treatment and study plan

Pleth variability index

Diagnostic Test

Pleth variability index

Pulse pressure variation

Diagnostic Test

Pulse pressure variation

Stroke volume variation

Diagnostic Test

Stroke volume variation

Right jugular vein distensibility index

Diagnostic Test

Right jugular vein distensibility index

Inferior Vena Cava Distensibility Index

Diagnostic Test

Inferior Vena Cava Distensibility Index

Primary outcomes

  1. Correlation Between the Right Internal Jugular Vein Distensibility Index and Inferior Vena Cava Distensibility Index

    Time frame: During a single assessment session on Day 1

    The association between the right internal jugular vein distensibility index (RJV-DI) and inferior vena cava distensibility index (IVC-DI), both expressed as percentages, will be quantified using Spearman's rank correlation coefficient.

Secondary outcomes

  1. Difference in Measurement Acquisition Time Between RJV-DI and IVC-DI

    Time frame: During a single assessment session on Day 1

    The time required to obtain technically adequate RJV-DI and IVC-DI measurements will be recorded in seconds. The paired acquisition times will be compared to determine which ultrasonographic assessment can be performed more rapidly.

Sponsors and collaborators

Lead sponsor

Gaziosmanpasa Research and Education Hospital

Other Gov

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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